外周穿刺中心静脉导管在胃肠癌FOLFOX6化学治疗方案中的临床应用

目的探讨外周穿刺中心静脉导管(PICC)在胃肠癌FOLFOX6化学治疗方案中的临床应用.观察其疗效和不良反应.方法 59例胃肠癌行FOLFOX6方案化学治疗患者,采用经外周静脉中心静脉置管(PICC)结合便携式化学治疗泵给药.方案为:奥沙利铂100 mg/m2静脉点滴2 h,第1天;亚叶酸钙400 mg/m2静脉点滴2 h,第1天;5-氟脲嘧啶(5-FU)400 mg/m2静推,第1天;后以5-FU 2.4 g/m2,入化学治疗泵持续静脉输注46 h,每2周重复.结果全组有效率49.2%(29/59),完全缓解10例、部分缓解19例、稳定17例、疾病进展13例.不良反应主要是外周神经炎、胃肠道反应、骨髓抑制,所有反应在停止治疗后可恢复.平均PICC置管时间为62 d;其中10.2%出现静脉炎,3.4%出现导管堵塞,6.8%出现导管移位,未出现严重相关并发症.结论胃肠癌患者采用经PICC管结合化学治疗泵FOLFOX6方案化学治疗,不仅提高化学治疗效果,降低不良反应,同时提高患者生活质量,值得临床推广.

Clinical experience of FOLFOX6 regimen in gastrointestinal cancer with PICC line

Objective To evaluate the efficacy and side effect of FOLFOX6 regimen in gastrointestinal cancer when it is given with PICC line(Peripherally Inserted Central Catheter).Methods 59 patients with gastrointestinal cancer were treated by FOLFOX6 regimen.FOLFOX6 regimen consisted of 2-hour infusion of oxaliplatin(100 mg/m2)and 2-hour infusion of leucovorin(CF)(400 mg/m2)on the first day,followed by 5-fluorouracil(5-FU)bolus(400 mg/m2)on the first day and 46-hour infusion(2.4 g/m2) used by chemotherapy pump.And a...