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Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: impact on laboratory diagnosis |
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| Authors: | Kim Heejung Riley Thomas V Kim Myungsook Kim Chang Ki Yong Dongeun Lee Kyungwon Chong Yunsop Park Jong-Woo |
| Affiliation: | Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea,1 Microbiology and Immunology, The University of Western Australia, Perth, Western Australia,2 Department of Laboratory Medicine, Chungnam National University, College of Medicine, Daejeon, Korea3 |
| Abstract: | Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A− B+). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A− B+ strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease. |
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