KLF14基因rs972283多态性与2型糖尿病的关系研究 |
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引用本文: | 史静,强丹,谢晓敏,李仁达,张丽,周海燕,于丽萍,李玲,邹晓燕,牛旭东,杨泽. KLF14基因rs972283多态性与2型糖尿病的关系研究[J]. 宁夏医学杂志, 2011, 33(12): 1151-1153,1140 |
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作者姓名: | 史静 强丹 谢晓敏 李仁达 张丽 周海燕 于丽萍 李玲 邹晓燕 牛旭东 杨泽 |
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作者单位: | 1. 宁夏银川市第一人民医院,宁夏,银川,750001 2. 国家卫生部北京医院老年医学研究所,北京,100730 |
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基金项目: | 宁夏自然科学基金项目(NZ08145) |
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摘 要: | 目的 研究KLF14基因rs972283多态性与宁夏2型糖尿病的关系.方法 用聚合酶链反应- 限制性片段长度多态性的方法(RFLP- PCR),对宁夏2型糖尿病患者(DM组)和正常对照组(NC组)KLF14基因rs972283位点进行基因多态性和等位基因频率分析,测定相应生化指标.结果 KLF14基因rs972283位点多态性在DM组和NC组的分布差异无统计学意义(P>0.05);DM组内携G等位基因患者的体质指数(BMI)、腰臀比(WHR)、血胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)均高于携A等位基因者,DM组内携G等位基因者胰岛β细胞功能(HOME-β)较携A等位基因者低,差异均有统计学意义(P<0.05).结论 KLF14基因rs972283位点多态性可能与宁夏2型糖尿病发病无关,与肥胖、血脂代谢等有关.
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关 键 词: | 2型糖尿病 KLF14基因 多态性 |
Relationship between polymorphism of KLF14 rs972283 and type 2 diabetes in Ningxia |
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Affiliation: | SHI Jing,et al.(The First People’s Hospital of Yinchuan,Yinchuan 750001,China) |
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Abstract: | Objective To investigate the relationship between polymorphism of KLF14 rs972283 and type 2 diabetes mellitus (T2DM) in Ningxia. Methods Polymerase chain reaction - restriction fragment length polymorphism ( PCR - RFLP) and case - control was used to analyze the KLF14 rs972283 and measure the clinical parameters in T2DM and the controls. Results There were no significant differences in genotypic and allelic frequ- encies of the KLF14 rs972283 polymorphism in T2DM and controls. The BMI, WHR, TC and HOMA - IR in patients with G allele of T2DM were significantly higher than those in the controls. The HOMA - 13in patients with G allele of T2DM were significantly lower than those in the control ( P 〈 0. 05 ). Conclusion The polymorphism of KLF14 rs972283 may have no relation with T2DM in Ningxia, but it may have relation with obesity and lipids metabolism. |
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Keywords: | Type 2 diabetes mellitus KLF14 gene Polymorphism |
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