| 副神经节瘤c-myc基因及其蛋白表达的初步研究 |
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| 引用本文： | 李锋,张仁元,施达仁,朱雄增,陆洪芬. 副神经节瘤c-myc基因及其蛋白表达的初步研究[J]. 农垦医学, 1995, 0(4) |
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| 作者姓名： | 李锋 张仁元 施达仁 朱雄增 陆洪芬 |
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| 作者单位： | 石河子医学院病理教研室(李锋)，上海医科大学肿瘤医院病理科(张仁元，施达仁，朱雄增，陆洪芬) |
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| 摘 要： | 本文运用免疫组化和原位分子杂交技术对50例副神经节瘤c-myc癌基因及其蛋白的表达进行了检测.免疫染色显示:c-myc蛋白阳性产物位于瘤细胞核内,总阳性率为28%(14/50),包括腹膜后、颈动脉体各6例,纵隔和肾上腺内各1例.8例原位杂交的病例中,5例可见瘤细胞浆内c-myc之mRNA的阳性杂交信号.本研究表明:c—myc的表达,可能与副节瘤的发生或生长状态有关.
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| 关 键 词： | 副神经节瘤 c-myc基因及蛋白 免疫 组织化学 原位分子杂交 |
EXPRESSION OF C-MYC GENE PRODUCTS IN PARAGANGLIOMAS |
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| Li reng. EXPRESSION OF C-MYC GENE PRODUCTS IN PARAGANGLIOMAS[J]. Agricultural Reclamation Medicine, 1995, 0(4) |
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| Authors: | Li reng |
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| Affiliation: | Li reng Department of pathology Sihezi Medical CollegeZhang Ren yuan; et al Department of pathology Cancer Hospital Shang hai Medical University |
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| Abstract: | Expression of c-myc protein and its mRNA were detected in fifty cases of paragangliomas by the techniques of Immunohistochemistray and In situ hybridization. Im-munostained results showed that :c-myc protein products located in the nuclear of tumor cells. The positive rate was 28%(14/50). There were 6 retroperitoneual, 6 carotid body, 1 mediastinal ,and 1 advenal pavagangliomas imtnunostained positively for c-myc protein, re-spectively. In situ hybridization were perforrned in 8 cases of paragangliomas. The positive signals of c-myc mRNA were detected in the cytoplasm of 5 cases of paragangliomas. Our results indicated that expression of c-myc oncogene may related to the tumorigenesis or the proliferation of paragangliomas. |
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| Keywords: | Paraganglioma c-myc gene and protein Immunohistochemistray In sitn hybridization. |
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