| 初诊急性白血病患儿细胞免疫功能研究 |
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| 引用本文： | 刘文彬,袁丽,许红波,刘华君,汤雪晴.初诊急性白血病患儿细胞免疫功能研究[J].西南国防医药,2005,15(4):367-369. |
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| 作者姓名： | 刘文彬 袁丽 许红波 刘华君 汤雪晴 |
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| 作者单位： | 成都军区总医院小儿科,四川,成都,610083 |
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| 摘 要： | 目的：探讨急性白血病患儿细胞免疫功能。方法：32例急性白血病外周血T淋巴细胞亚群、血清白介素-2（IL-2）及可溶性白介素-2受体（sIL-2）水平检测，分别采用APAAP法、ELISA法和双抗体夹心酶联免疫吸附法。结果：与对照组比较，急性白血病患儿外周血CD3、CD4、CD8百分率、CD4／CD8比值以及血清IL-2水平明显降低（P〈0．01），IL-2R水平则明显升高（P〈0．01），sIL-2R水平则明显升高（P〈0．01）。结论：急性白血病患儿细胞免疫功能低下且紊乱。
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| 关 键 词： | 急性白血病 T淋巴细胞亚群 白细胞介素-2 白细胞介素-2受体 儿童 |
| 文章编号： | 1004-0188（2005）04-0367-03 |
| 收稿时间： | 2005-05-09 |
| 修稿时间： | 2005年5月9日 |
Study of cellular immune function in children with acute leukemia |
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| LIU Wen-bin,YUAN Li,XU Hong-bo,LIU Hua-jun,TANG Xue-qing.Study of cellular immune function in children with acute leukemia[J].Medical Journal of National Defending forces in Southwest China,2005,15(4):367-369. |
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| Authors: | LIU Wen-bin YUAN Li XU Hong-bo LIU Hua-jun TANG Xue-qing |
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| Abstract: | Objective: To study of cellular immune function in children with acute leukemia. Methods: The levels of T lymphocyte subsets, serum interleukin-2(IL-2) and soluble interleukin-2 receptor(sIL-2R) of children with acute leukemia were determined by APAAP, ELISA and double-antibody sandwich enzyme-linked immunoassay method, respectively. Results: The percentages of CD3, CD4, CD8 and the ratio of CD4 and CD8 as well as the level of IL-2 were lower, while the level of sIL-2R was higher in these children than those in the healthy children(P<0.01). Conclusion: The children with acute leukemia have a poor cellular immune function. |
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| Keywords: | acute leukemia cellular immunity interleukin T lymphocyte subset pediatrics |
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