三阴性乳腺癌的临床病理特征及预后分析

目的探讨三阴性乳腺癌的临床病理特征及生存情况。方法收集2004年1月-2009年12月武汉大学中南医院及湖北省肿瘤医院确诊的乳腺癌患者560例，对比分析三阴性乳腺癌患者情况。结果三阴性乳腺癌多见于绝经前女性，肿瘤直径大，组织学分级高，淋巴结转移率高，5年无瘤生存率及总生存率均低于非三阴性乳腺癌，二者差别有统计学意义。绝经与否、肿瘤直径大小以及淋巴结有无转移与其预后相关。 结论三阴性乳腺癌是一类预后差的乳腺癌亚型。

Analysis of Chinicopathological Characteristics and Prognosis of Triple Negative Breast Cancer

Objective To investigate the clinical pathological characteristics,survival and prognostic factors of patients with triple negative breast cancer.Methods The clinical and pathological data of 560 patients,confirmed as breast cancer in Zhongnan hospital of Wuhan university and hubei cancer hospital from Jan 2004 to Dec 2009,were collected.We analyzed the clinical characteristics,recurrence rate and survival rate of the triple-negative breast cancer(TNBC) patients by comparing the characteristics between the two groups(TNBC and non-TNBC groups).Results Compared with non-TNBC group,the patients of TNBC group were usually young,associated with large masses,high histological grade and lymph node metastasis.There were significant differences in median survival time and the 5-year disease-free rate between TNBC group and non-TNBC group.Tumor mass,lymph node metastasis and menopause were important prognostic factors.Conclusion Triple negative breast cancer is one subtype of breast cancer with poor prognosis.