| microRNA-130a在非小细胞肺癌中的表达及其意义 |
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| 引用本文： | 王永涛,孙小亮,崔玉忠,赵如森.microRNA-130a在非小细胞肺癌中的表达及其意义[J].肿瘤防治研究,2012,39(3):278-280. |
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| 作者姓名： | 王永涛 孙小亮 崔玉忠 赵如森 |
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| 作者单位： | 1.255400 山东淄博，临淄区人民医院肿瘤内科；2.北京协和医学院肿瘤医院内科 |
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| 摘 要： | 目的探讨microRNA-130a在非小细胞肺癌中的表达情况及其临床意义。方法应用Real-time PCR方法检测100例非小细胞肺癌患者组织标本中microRNA-130a的表达水平，结合临床病理资料进行统计学分析。结果非小细胞肺癌组织中microRNA-130a的表达水平升高，而且其表达与淋巴结转移和临床分期有显著相关性（P< 0.05）。此外，microRNA-130a的表达与患者吸烟有显著相关性（P< 0.05）。多因素分析发现临床分期、淋巴结转移、microRNA-130a的表达对预后的影响有显著相关性（P< 0.01）。结论microRNA-130a将来可能作为非小细胞肺癌诊断和预后判断的分子标志物。
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| 关 键 词： | 非小细胞肺癌 microRNA-130a 转移 预后 |
| 收稿时间： | 2011-08-04 |
Expression and Significance of microRNA-130a in Non-small Cell Lung Cancer |
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| Wang Yongtao
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Sun Xiaoliang
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Cui Yuzhong
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Zhao Rusen.Expression and Significance of microRNA-130a in Non-small Cell Lung Cancer[J].Cancer Research on Prevention and Treatment,2012,39(3):278-280. |
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| Authors: | Wang Yongtao Sun Xiaoliang Cui Yuzhong Zhao Rusen |
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| Institution: | 1.Department of Internal Medicine，Linzi District People’s Hospital of ZiBo，Zibo 255400，China； 2.Department of Internal Medicine，Cancer Hospital，Chinese Academy of Medical Sciences |
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| Abstract: | Objective To investigate the expression of microRNA-130a in non-small cell lung cancer and analyze their correlation with clinical parameters.Methods Real-time PCR method was used to examine 100 samples of non-small cell lung cancer.Results The expression of microRNA-130a in non-small cell lung cancer was increased.It’s expression was significantly associated with lymph node metastasis and clinical stage(P< 0.05).Multivariate analysis showed the prognosis was statistically correlated with clinical stage,lymph node metastasis and microRNA-130a expression(P< 0.01).Conclusion microRNA-130a might play an important role in non-small cell lung cancer and thus be the potential gene therapy target for this cancer. |
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| Keywords: | Non-small cell lung cancer microRNA-130a Metastasis Prognosis |
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