Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases |
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| Authors: | Claudia Paternostro Ezio David Erica Novo Maurizio Parola |
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| Institution: | Claudia Paternostro, Erica Novo, Maurizio Parola, Department of Experimental Medicine and Oncology, Interuniversity Centre for Hepatic Pathophysiology, University of Torino, Corso Raffaello 30, 10125 Torino, ItalyEzio David, Department of Pathology, San Giovanni Battista Hospital, 10126 Torino, Italy |
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| Abstract: | Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood vessels.Experimental and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive fibrogenesis.Angiogenesis and related changes in liver vascular architecture,th... |
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| Keywords: | Chronic liver diseases Hepatic myofibroblasts Hypoxia Liver angiogenesis Liver fibrogenesis |
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