| 当归四逆加吴茱萸生姜汤和北细辛对小鼠肾脏组织细胞Ca2+、Na+-K+-ATP酶的影响 |
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| 引用本文： | 邓毅,王昕,张艳萍,姚凝,杨志军.当归四逆加吴茱萸生姜汤和北细辛对小鼠肾脏组织细胞Ca2+、Na+-K+-ATP酶的影响[J].中国中医药信息杂志,2006,13(1):35-36. |
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| 作者姓名： | 邓毅 王昕 张艳萍 姚凝 杨志军 |
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| 作者单位： | 1. 甘肃中医学院,甘肃,兰州,730000
2. 甘肃中医学院附属医院,甘肃,兰州,730020 |
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| 摘 要： | 目的观察当归四逆加吴茱萸生姜汤(原方)、原方去木通和北细辛对肾脏毒性的作用。方法将小鼠随机分为4组,各组分别以生理盐水及药物灌胃,每日1次,连续给药21d。检测各组对小鼠肾脏组织细胞Ca2 含量、Na -K -ATP酶活性的影响。结果当归四逆加吴茱萸生姜汤等药物组对组织细胞Ca2 、Na -K -ATP酶等指标均有影响,具有统计学意义(P<0.05)。结论当归四逆加吴茱萸生姜汤(原方)组、原方去木通组、北细辛组对肾脏均产生毒性。
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| 关 键 词： | 中药复方 北细辛 肾损害 钙离子 Na -K -ATP酶 |
| 文章编号： | 1005-5304（2006）01-0035-02 |
| 收稿时间： | 2004-12-20 |
| 修稿时间： | 2004年12月20 |
Experimental Studies on Effect of Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum Heterotropoides Fr.var. mandshuricum Kitag. on Ca2+ and Na+-K+-ATPase of the Small Mices' Renalis |
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| DENG Yi, WANG Xi, ZHANG Yan-ping, et al.Experimental Studies on Effect of Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum Heterotropoides Fr.var. mandshuricum Kitag. on Ca2+ and Na+-K+-ATPase of the Small Mices'' Renalis[J].Chinese Journal of Information on Traditional Chinese Medicine,2006,13(1):35-36. |
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| Authors: | DENG Yi WANG Xi ZHANG Yan-ping |
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| Institution: | 1.Gansu College of TCM, Lanzhou 730000, China ; 2, The Affiliated Hospital Gansu College of TCM, Lanzhou 730020, China |
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| Abstract: | Objective To approach the toxicity of Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum heterotropoides Fr.var. mandshuricum Kitag. Method To observe the Ca2 , Na -K -ATPase from the mice renalis tissue in order to prove the medicine curative effect. Result The Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum heterotropoides Fr.var. mandshuricum Kitag. can obviously increase the Ca2 and decrease the Na -K -ATPase of the mice. Conclusion The Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum heterotropoides Fr.var. mandshuricum Kitag. has very obviously toxicity to mice by influence the Ca2 and Na -K -ATPase of the tissue homogenate. |
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| Keywords: | Danggui Sini plus Wuzhuyu Shengjiang Tang Asarum heterotropoides Fr var mandshuricum Kitag renalis injury Ca2 Na -K -ATPase |
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