| 血浆HSP70在CUMS诱导抑郁样行为过程中的变化规律 |
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| 引用本文： | 战锐,武磊,弓景波,王新兴,赵云,冷雪,钱令嘉.血浆HSP70在CUMS诱导抑郁样行为过程中的变化规律[J].军事医学科学院院刊,2011,35(9):672-675. |
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| 作者姓名： | 战锐 武磊 弓景波 王新兴 赵云 冷雪 钱令嘉 |
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| 作者单位： | 1. 军事医学科学院基础医学研究所全军军事认知与心理卫生研究中心,北京,100850
2. 军事医学科学院卫生学环境医学研究所,天津,300050 |
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| 基金项目： | 国家自然科学基金资助项目(8100058431071022); 国家“重大新药创制”科技重大专项资助项目(2008ZXJ09014-011) |
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| 摘 要： | 目的观察慢性不可预计温和应激（chronic unpredictable mild stress,CUMS）诱导抑郁样行为过程中血浆HSP70水平的变化规律,探讨血浆HSP70作为诊断抑郁症的分子标志物的可能性。方法利用CUMS建立大鼠抑郁动物模型,电子秤称量大鼠体质量,糖水偏爱实验、旷场实验评定CUMS模型大鼠行为学的变化,双抗夹心酶联免疫方法检测血浆HSP70水平。结果 （1）在第4～8周,CUMS模型大鼠的糖水偏爱度较对照组显著下降（P〈0.05）,并呈现逐渐降低的趋势;（2）CUMS模型大鼠的运动行为较对照组呈现先升高后降低的趋势,第6、8周CUMS模型大鼠的旷场实验评分较对照组明显降低（P〈0.05）;（3）第2、4、6、8周CUMS模型大鼠体质量与对照组相比显著下降（P〈0.05）;（4）第4、6、8周CUMS模型大鼠血浆HSP70水平较对照组显著升高（P〈0.05）,并呈现逐渐升高的趋势。结论 CUMS可诱导大鼠产生抑郁样行为,在大鼠抑郁样行为形成过程中,血浆HSP70出现逐渐升高的趋势,提示血浆HSP70具有成为抑郁症诊断生物标志物的可能性。
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| 关 键 词： | 抑郁症 应激 慢性不可预计温和应激 HSP70 生物标志物 |
Change of the level of plasma HSP70 in depression rats induced by chronic unpredictable mild stress |
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| ZHAN Rui,WU Lei,GONG Jing-bo,WANG Xin-xing,ZHAO Yun,LENG Xue,QIAN Ling-jia.Change of the level of plasma HSP70 in depression rats induced by chronic unpredictable mild stress[J].Bulletin of the Academy of Military Medical Sciences,2011,35(9):672-675. |
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| Authors: | ZHAN Rui WU Lei GONG Jing-bo WANG Xin-xing ZHAO Yun LENG Xue QIAN Ling-jia |
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| Institution: | ZHAN Rui 1,WU Lei 2,GONG Jing-bo 1,WANG Xin-xing 1,ZHAO Yun 1,LENG Xue 2,QIAN Ling-jia 1*(1.Institute of Basic Medical Sciences,Research Center for Military Cognition and Mental Hygiene of PLA,Academy of Military Medical Sciences,Beijing 100850,China,2.Institute of Health and Environmental Medicine,Tianjin 300050,China) |
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| Abstract: | Objective To observe the change of plasma HSP70 in depression rats induced by chronic unpredictable mild stress(CUMS) and investigate the possibility of plasma HSP70 being used as the diagnostic biomarker for depression.Methods Depression was induced by CUMS,body mass was measured by the electronic animal scale,and sucrose preference test and open-field test were applied to evaluate the behavior of the CUMS rats.The plasma HSP70 level was detected by ELISA.Results(1)Preference sucrose of the CUMS rats decre... |
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| Keywords: | depression stress chronic unpredictable mild stress HSP70 biomarker |
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