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Potential Effect of Using ABO-Compatible Living-Donor Liver Transplantation |
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| Authors: | E. Chaib C. Fridman |
| Affiliation: | a Liver Surgery Unit, Department of Gastroenterology, Hospital das Clinicas, University of São Paulo School of Medicine, São Paulo, Brazil b LIM 01-HCFMUSP, University of São Paulo School of Medicine, São Paulo, Brazil c LIM 40-HCFMUSP, University of São Paulo School of Medicine, São Paulo, Brazil d Department of Medical Informatics, LIM 01, University of São Paulo School of Medicine, São Paulo, Brazil e Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, England |
| Abstract: | Liver transplantation increased 1.84-fold from 1988 to 2004. However, the number of patients on the waiting list for a liver increased 2.71-fold, from 553 to 1500. We used a mathematical equation to analyze the potential effect of using ABO-compatible living-donor liver transplantation (LDLT) on both our liver transplantation program and the waiting list. We calculated the prevalence distribution of blood groups (O, A, B, and AB) in the population and the probability of having a compatible parent or sibling for LDLT. The incidence of ABO compatibility in the overall population was as follows: A, 0.31; B, 0.133; O, 0.512; and AB, 0.04. The ABO compatibility for parent donors was blood group A, 0.174; B, 0.06; O, 0.152; and AB, 0.03; and for sibling donors was A, 0.121; B, 0.05; O, 0.354; and AB, 0.03. Use of LDLT can reduce the pressure on our liver transplantation waiting list by decreasing its size by at least 16.5% at 20 years after its introduction. Such a program could save an estimated 3600 lives over the same period. |
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