| 肾移植受者霉酚酸临床药代动力学研究 |
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| 引用本文： | 任斌,元刚,傅晓华. 肾移植受者霉酚酸临床药代动力学研究[J]. 现代食品与药品杂志, 2011, 0(10) |
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| 作者姓名： | 任斌 元刚 傅晓华 |
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| 作者单位： | 中山大学附属第一医院;广州新海医院; |
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| 摘 要： | 目的研究肾移植受者的霉酚酸(MPA)药代动力学。方法 采用高效液相色谱法监测19名肾移植受者术后多剂量口服霉酚酸酯(MMF)后的MPA血药浓度,采用非线性混合效应模型法计算多剂量口服达稳态的MPA药代动力学参数。结果 MPA达峰时间Tmax为1.0 h,峰浓度Cmax为8.3μg/ml,谷浓度Cmin为2.6μg/ml,药时曲线下面积AUC0～12 h为44.9μg.h/ml。MPA药动学参数群体值CL=27.7 L/h,Vd=85.3 L,个体间变异分别为22.0%2、5.7%。结论本研究建立的群体药动学模型可较准确地描述MPA在肾移植受者的药动学特征,其预测能力尚需进一步评估。
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| 关 键 词： | 霉酚酸 药代动力学 肾移植 高效液相色谱法 |
Pharmacokinetic Study of Mycophenolic Acid in Renal Transplant Recipients |
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| REN Bin,YUAN Gang,FU Xiao-hua. Pharmacokinetic Study of Mycophenolic Acid in Renal Transplant Recipients[J]. JOurnal of Modern Food and Pharmaceuticals, 2011, 0(10) |
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| Authors: | REN Bin YUAN Gang FU Xiao-hua |
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| Affiliation: | REN Bin1,YUAN Gang1,FU Xiao-hua2 (1.The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,Guangdong 510080,China,2.Guangzhou Xinhai Hospital,Guangdong 510300,China) |
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| Abstract: | Objective To investigate the pharmacokinetic parameters of mycophenolic acid(MPA) in 19 adult renal transplant recipients.Methods High performance liquid chromatography(HPLC) was used for therapeutic drug monitoring of mycophenolic acid in the study.The pharmacokinetic parameters of multiple doses MMF were calculated by nonlinear mixed effect model.Results The mean pharmacokinetic parameters of multiple oral dose MMF were as follows: the mean time for drug to reach peak leval in plasma(Tmax) was 1.0 h,the m... |
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| Keywords: | mycophenolic acid pharmacokinetic renal transplantation high performance liquid chromatography |
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