甲状腺癌COX-2和VEGF的表达与血管生成及临床病理的关系

目的：探讨环氧合酶-2（COX-2）与甲状腺肿瘤血管生成的关系，研究COX-2和血管内皮生长因子（VEGF）在甲状腺癌中的表达及临床意义。方法：应用免疫组织化学方法检测60例甲状腺癌、15例甲状腺腺瘤及10例正常甲状腺组织中COX-2和VEGF的表达，并对甲状腺癌组织学分型、临床病理分期及淋巴结转移进行对比分析。结果：COX-2和VEGF在甲状腺癌中的表达明显高于甲状腺腺瘤(P<0.01)，正常甲状腺组织未见表达；甲状腺癌中COX-2与VEGF的表达呈正相关（r＝0.636,P<0.01）。二者表达均与甲状腺癌组织学分型、临床病理分期及淋巴结转移有关（P<0.05）。结论： COX-2和VEGF在甲状腺癌中呈高表达。COX-2可能通过多种途径促进甲状腺癌的发生和发展；COX-2对VEGF的高表达可能具有潜在的正向调控作用，进而影响甲状腺癌的浸润和转移。

Relationships between COX-2 and VEGF expressions and angiogenesis and clinical pathology in thyroid cancer

Objective To investigate the relationships between Cyclooxygenase(COX-2) and angiogenesis and expressions of COX-2 and vascular endothelial growth factor(VEGF) in thyroid cancer and its clinical significance.Methods Immunohistochemistry was used to detect the expressions of COX-2 and VEGF in 60 thyroid cancer,(15 thyroid)adenomas and 10 normal thyroid tissues.Results The expression rates of COX-2 and VEGF in thyroid cancer were higher than those in thyroid adenomas and normal tissues(P<0.01).The expressions of COX-2 and VEGF in thyroid cancer presented positive correlation(r=0.636,P<0.01).The expression rates of COX-2 in thyroid papillary cancer and undifferentiated cancer were 47.1% and 90.0% .The expression rates of VEGF in thyroid papillary cancer and undifferentiated cancer were 71.4% and 100%.The expression rates of COX-2 and VEGF in TNM Ⅰ and Ⅱ were lower than those in TNM Ⅲ and Ⅳ(P<0.05).The expression rates of COX-2 and VEGF in thyroid cancer with lymph node metastasis were higher those that without lymph node metastasis((P<0.05).)Conclusion COX-2 and VEGF express highly in thyroid cancer.The expressions of COX-2 and VEGF in thyroid cancer correlates with pathological type,TNM phase and lymph node metastasis of thyroid cancer.