保心安胶囊治疗心肌梗死后心力衰竭的临床疗效及对患者心功能、N末端B型利钠肽原的影响

目的观察保心安胶囊治疗心肌梗死后心力衰竭的临床疗效及对患者心功能、血浆N末端B型利钠肽原(NT-pro BNP)的影响。方法将88例心肌梗死后心力衰竭患者随机分为2组,对照组44例在原发病治疗基础上予以单硝酸异山梨酯片、阿司匹林肠溶片、氯吡格雷片、阿托伐他汀片、卡托普利片、美托洛尔片、螺内酯片等常规药物的常规剂量,治疗组44例在对照组治疗基础上加用保心安胶囊治疗。2组均15 d为1个疗程,1个疗程后观察疗效,并观察2组治疗前后心功能分级、血浆NT-pro BNP、超声心动图左室射血分数(LVEF)及左室舒张末内径(LVEDD)及24 h动态心电图的变化。结果治疗组总有效率90.9%,对照组总有效率77.3%,2组比较差异有统计学意义(P0.05),治疗组疗效优于对照组。2组治疗后LVEF、LVEDD、血浆NT-pro BNP含量、24 h动态心电图心律失常的发作次数和时间均改善(P0.05),且治疗组改善优于对照组(P0.05)。2组治疗后尿量增加,血压、心率、体质量均降低,与本组治疗前比较差异均有统计学意义(P0.05),且治疗组改善优于对照组(P0.05)。结论保心安胶囊可明显改善心肌梗死后心力衰竭患者的临床症状,降低血浆NT-pro BNP含量,改善心脏结构,改善心功能,减少心律失常的发生。

Clinical effects of Baoxin'an capsule on heart failure after myocardial infarction and its effects on heart function and NT-proBNP of patients

Objective To observe the clinical effects of Baoxin''an capsule on heart failure after myocardial infarction and its effects on heart function and N-terminal pro-brain natriuretic peptide (NT-proBNP) of patients.Methods 88 patients with heart failure after myocardial infarction were randomly divided into two groups.The control group (n=44) was given the conventional dose of lsosorbide mononitrate tablets, aspirin enteric-coated tablets, clopidogrel tablets, atorvastatin tablets, metoprolol tablets, and spironolactone tablets and other conventional drugs on the basis of primary disease treatment.The treatment group (n=44) was treated by Baoxin''an capsule on the basis of control group.The treatment course was 15 d in two groups.After one course, the curative effects were observed, and the changes of heart function classification,plasma NT-proBNP, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), and 24 h dynamic electrocardiogram before and after treatment were observed.Results The total effective rate in treatment group (90.9%) was superior to that in control group (77.3%, P<0.05).The LVEF, LVEDD, plasma NT-proBNP content, arrhythmia episodes and time of 24 h dynamic electrocardiogram after treatment were improved in two groups (P<0.05), and the improvement in treatment group was superior to that in control group (P<0.05).The urine volume after treatment increased in two groups, and blood pressure, heart rate, body mass reduced (P<0.05), and the improvement in the treatment group was better than that in control group (P<0.05).Conclusion Baoxing''an capsule can significantly improve the clinical symptoms of patients with heart failure after myocardial infarction, reduce the plasma content of NT-proBNP, improve heart structure and heart function, and reduce the occurrence of arrhythmias.