健脾补肾汤对卵巢早衰患者血清性激素水平及外周血T淋巴细胞亚群的影响

目的观察健脾补肾汤对卵巢早衰患者血清性激素水平及外周血T淋巴细胞亚群的影响。方法将60例卵巢早衰患者随机分为2组。对照组30例予激素替代疗法治疗,治疗组30例予健脾补肾汤治疗,2组均3个月为1个疗程,治疗1个疗程后统计临床疗效。检测2组治疗前后血清性激素包括血清卵泡刺激素(FSH)、雌二醇(E_2)、黄体生成激素(LH)、孕酮(P)、催乳素(PRL)]水平及外周血T淋巴细胞亚群T淋巴细胞总数、CD3~+、CD4~+、CD8~+、CD4~+/CD8~+变化,并进行统计学分析,比较2组临床疗效及不良反应发生情况。结果治疗组总有效率73.33%,对照组总有效率76.67%,2组总有效率比较差异无统计学意义(P0.05),疗效相当。2组治疗后FSH、LH及PRL水平均较本组治疗前降低,E_2及P水平升高,比较差异均有统计学意义(P0.05)。治疗后2组组间比较显示,治疗组LH及PRL水平低于对照组,E_2及P水平高于对照组,比较差异均有统计学意义(P0.05)。2组治疗后外周血T淋巴细胞总数、CD3~+、CD4~+及CD4~+/CD8~+均较本组治疗前升高,CD8~+降低,且治疗组治疗后CD4~+高于对照组,比较差异均有统计学意义(P0.05)。治疗组30例在治疗过程中无不良反应发生,对照组不良反应发生率为20.0%,治疗组不良反应发生率明显低于对照组(P0.05)。结论健脾补肾方治疗卵巢早衰疗效显著,可促进患者血清性激素水平恢复正常,调节机体免疫,安全有效。

Effects of Jianpi-bushen decoction on serum hormone levels and peripheral blood T lymphocyte subsets in patients with premature ovarian failure

Objective To observe the effects of Jianpi-bushen decoction on serum hormone levels and peripheral blood T lymphocyte subsets in patients with premature ovarian failure.Methods 60 patients with premature ovarian failure were randomly divided into two groups.The control group (n=30) was treated by hormone-replacement therapy, and the treatment group (n=30) was treated by Jianpi-bushen decoction.The treatment course was 3 month in two groups, and the curative effects were evaluated after 1 treatment course.The serum sex hormones including serum follicle-stimulating hormone (FSH), estradiol(E2), luteinizing hormone (LH), progesterone (P), prolactin (PRL), and the total number peripheral blood T lymphocyte,CD3+, CD4+, CD8+, CD4+/CD8+ before and after treatment were detected and statistically analyzed in two groups.The clinical effects and adverse reactions were compared in two groups.Results There was no statistical difference on the total effective rate between the treatment group (73.33%) and the control group (76.67%, P>0.05), with equivalent efficacy.The FSH, LH and PRL after treatment reduced in two groups, the E2 and P increased, with statistical differences (P<0.05).The LH and PRL after treatment in treatment group were lower than those in control group, and the E2 and P were higher, with statistical differences (P<0.05).The total number of peripheral blood T lymphocyte,CD3+, CD4+ and CD4+/CD8+ after treatment increased, and CD8+ reduced in two groups,and CD4+ after treatment in treatment group was higher than that in control group, with statistical differences (P<0.05).In the treating process, 30 cases in the treatment group without adverse reactions occurring, the incidence of adverse reactions in the control group was 20.0%.The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P<0.05).Conclusion Jianpi-bushen decoction has significant effects on premature ovarian failure, can promote the serum hormone levels return to normal and regulate the body immunity, safe and effective.