滋阴通脉胶囊联合西医治疗早期糖尿病肾病80例临床观察

目的观察滋阴通脉胶囊联合西医治疗早期糖尿病肾病临床疗效。方法将80例辨证属气阴两虚、瘀阻脉络证早期糖尿病肾病患者随机分为2组。对照组40例予西医常规治疗,治疗组40例在对照组治疗基础上加用滋阴通脉胶囊治疗。2组均治疗3个月后统计疗效,并观察2组治疗前后胆固醇(TC)、甘油三酯(TG)、尿微量白蛋白排泄率(UAER)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(Hb A1c)变化。结果治疗组总有效率92.50%,对照组总有效率75.00%,2组比较差异有统计学意义(P0.05),治疗组疗效优于对照组。对照组治疗后TG、TC与本组治疗前比较差异均无统计学意义(P0.05),对照组治疗后UAER降低,与本组治疗前比较差异有统计学意义(P0.05)。治疗组治疗后TG、TC、UAER均降低,与本组治疗前比较差异均有统计学意义(P0.05)。2组治疗后TG、TC、UAER比较差异均有统计学意义(P0.05)。2组治疗前后FPG、2 h PG、Hb A1c组内及组间比较差异均无统计学意义(P0.05)。结论滋阴通脉胶囊联合西医治疗早期糖尿病肾病疗效确切,并能改善TC、TG及UAER水平。

Clinical observation of Ziying-tongmai capsules on the treatment of early diabetic nephropathy

Objective To observe the clinical effects of Ziying-tongmai capsules on the treatment of early diabetic nephropathy.Methods 80 early diabetic nephropathy patients with Qi-Yin deficiency type and blood stasis blocking collaterals type were randomly divided into two groups.The control group (n=40) were treated by western medicine routine treatment, the treatment group (n=40) were treated by Ziying-tongmai capsules on the basis of the control treatment.The curative effects were evaluated after 3 months treatment in two groups.The serum total cholesterol (TC), triglyceride (TG) and urine albumin excretion ratio (UAER) fasting plasma-glucose (FPG),2 h postprandial glucose(2 hPG) and glycosylated hemoglobin (HbA1c) before and after treatment were observed in two groups.Results The total effective rate in treatment group (92.50%) was superior to that in control group (75.0%, P<0.05).There were no statistical differences on TG and TC between before and after treatment in control group (P>0.05).The UAER after treatment in control group was lower than that in before treatment (P<0.05).The TG, TC and UAER after treatment in treatment group were lower than those in before treatment (P<0.05).There were statistical differences on TG, TC and UAER after treatment between two groups (P<0.05).There were no statistical differences FPG,2 hPG and HbA1c befor and after treatmet intra and between two groups (P>0.05).Conclusion Ziying-tongmai capsules has exact effects on the treatment of early diabetic nephropathy, can improve the levels of TC, TG and UAER.