新型炎症因子与原发性骨质疏松症的研究进展

原发性骨质疏松症的发病机制至今仍未完全明确.骨骼免疫学的提出进一步映证了慢性炎症在骨质疏松症(osteoporosis,OP)发生中的重要作用,多项炎症因子及免疫细胞参与其中.中性粒细胞/淋巴细胞比率(neutrophil-to-lymphocyte ratio,NLR)、全身免疫炎症指数(systemic immun...

Research progress of novel inflammatory factors in primary osteoporosis

The pathogenesis of primary osteoporosis is extremely complex and has not been fully elucidated up to now.The development of bone immunology further demonstrates the important role of chronic inflammation in the development of osteoporosis, in which multiple inflammatory factors and immune cells are involved.As indicators reflecting systemic inflammation,neutrophil-to-lymphocyte ratio(NLR) and Systemic Immune-Inflammation Index (SII) are of low cost and stable monitoring, with obvious advantages. At present, studies have confirmed that they can be combined with other inflammatory indicators and markers of bone transformation to early diagnose osteoporosis and even predict osteoporotic fractures.Compared with the current screening methods for osteoporosis commonly used clinically, it can avoid time-consuming, laborious and delayed results, improve patients'' compliance, and facilitate early detection of osteoporosis and timely intervention.