富血小板血浆与透明质酸治疗膝骨性关节炎的荟萃分析

[目的]比较关节腔内注射富血小板血浆(platelet-rich plasma,PRP)和透明质酸(hyahronic acid,HA)治疗膝关节骨性关节炎(knee osteoarthritis,KOA)的临床疗效.[方法]系统检索Cochrane、PubMed和Embase数据库中截至2020年12月所有关节腔内注...

Platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis:a meta-analysis

[Objective]To compare the clinical outcomes of platelet-rich plasma(PRP)versus hyaluronic acid(HA)intraarticularly for treatment of knee osteoarthritis(KOA).[Methods]All randomized controlled trials on the clinical efficacy of intraarticularly PRP and HA in the treatment of KOA were systematically searched from Cochrane,PubMed and Embase databases as of December 2020.After quality assessment,the data were extracted from the literature,and then a meta-analysis of data was performed using Review Manager 5.3 software.[Results]A total of 13 studies were enrolled into this study involving 1259 patients,including 644 patients in the PRP group and 615 patients in the HA group,with a followed-up period of 12 months.As results of this meta-analysis,the PRP group proved significantly superior to the HA group in terms of overall WOMAC scores(MD=-16.57,95%CI=-23.34?-9.79,P<0.001),WOMAC function score(SMD=-1.47,95%CI=-2.34?-0.59,P<0.001),WOMAC pain score(SMD=-1.02,95%CI=-1.69?-0.34,P=0.002),and VAS score (SMD=-2.75,95%CI=-4.93?-0.57,P=0.013).However,there was no a significant difference in the incidence of adverse reactions between the two groups(RR=1.07,95%CI=0.80?1.42,P=0.100).[Conclusion]The PRP is superior to the HA in alleviating pain and functional recovery for treatment of KOA,but there is no difference in safety between the two therapies.