| 自噬/苄氯素1调节因子1在自噬与凋亡中作用的研究进展 |
| |
| 引用本文： | 尚画雨,付玉,马穰桂,夏志. 自噬/苄氯素1调节因子1在自噬与凋亡中作用的研究进展[J]. 中国病理生理杂志, 2021, 0(1): 173-180 |
| |
| 作者姓名： | 尚画雨 付玉 马穰桂 夏志 |
| |
| 作者单位： | 成都体育学院运动医学与健康学院;井冈山大学体育学院 |
| |
| 基金项目： | 国家自然科学基金资助项目(No.31900842,No.31960192);国家体育总局运动医学重点实验室资助项目(No.CX17B07);江西省自然科学基金资助项目(No.20192BAB205081);江西省教育厅科技项目重点项目(No.GJJ180560);江西省杰出青年基金资助项目(No.20202ACBL216004)。 |
| |
| 摘 要： | 细胞凋亡(Ⅰ型程序性死亡)和自噬性细胞死亡(Ⅱ型程序性死亡)这2种细胞死亡方式可通过一些蛋白的相互作用而介导形成平衡对立状态.一方面,细胞凋亡由胱天蛋白酶(caspase,CASP)依赖性通路经内源性、外源性或内质网应激诱导途径予以控制,而死亡信号则可经这3种途径介导受损或感染细胞的清除[1-2].另一方面,细胞自噬由...
|
| 关 键 词： | 自噬/苄氯素1调节因子1 自噬 细胞凋亡 线粒体自噬 癌症 |
Research progress on role of autophagy/beclin-1 regulator 1 in autophagy and apoptosis |
| |
| SHANG Hua-yu,FU Yu,MA Rang-gui,XIA Zhi. Research progress on role of autophagy/beclin-1 regulator 1 in autophagy and apoptosis[J]. Chinese Journal of Pathophysiology, 2021, 0(1): 173-180 |
| |
| Authors: | SHANG Hua-yu FU Yu MA Rang-gui XIA Zhi |
| |
| Affiliation: | (School of Sports Medicine and Health,Chengdu Sport University,Chengdu 610041,China;Physical Education College of Jinggangshan University,Ji'an 343009,China) |
| |
| Abstract: | There are complex interactions between autophagy and apoptosis,which can be mediated by specific proteins that play a dual role.Autophagy/beclin-1 regulator 1(AMBRA1)is one of the receptor proteins involved in both autophagy and apoptosis.Recent studies show that AMBRA1 not only interacts with beclin-1,classⅢphosphatidylinositol 3-kinase(PI3KⅢ/VPS34)and a variety of E3 ubiquitin ligases in the cytoplasm to induce autophagy,but also transfers to mitochondria and interacts with microtubule-associated protein 1 light chain 3B(LC3B)to mediate mitophagy.In addition,AMBRA1 is a direct substrate of apoptotic protease(caspase)and its cleavage displays a pro-apoptotic or antiapoptotic activity.This article reviews the role and mechanism of AMBRA1 in regulating autophagy and apoptosis. |
| |
| Keywords: | Autophagy/beclin-1 regulator 1 Autophagy Apoptosis Mitophagy Cancer |
| 本文献已被 CNKI 维普 等数据库收录！ |
