Hcy、BNP和VEGF-B在STEMI患者血清中水平变化的分析

目的 研究同型半胱氨酸(Hcy)、脑钠肽(BNP)和血管内皮细胞生长因子-B(VEGF-B)在ST段抬高型心肌梗死(STEMI)患者血清中的水平变化及其对不良心血管事件(MACE)发生风险的预测价值.方法 以2019年1月至2020年1月收治的S T E M I患者120例作为研究对象,按是否有M A C E发生分为M...

Changes of Hcy,BNP and VEGF-B levels in serum of STEMI patient

Objective To study the changes of Hcy,BNP and VEGF-B levels in serum of STEMI patients and their predictive value for the risk of major adverse cardiovascular events(MACE).Methods Totally 120 STEMI patients from January 2019 to January 2020 were selected as the research objects,including 27 patients with MACE(MACE group)and 93 patients without MACE(non MACE group).The differences of Hcy,BNP and VEGF-B levels between the two groups were compared,and the predictive effect of combined detection of Hcy,BNP and VEGF-B levels on MACE was analyzed.Results Hcy(t=22.976,P<0.001)and BNP(t=14.876,P<0.001)in MACE group were significantly higher than those in non-MACE group,and VEGF-B(t=139.157,P<0.001)were significantly lower than those in non-MACE group.The specificity of combined detection of Hcy,BNP and VEGF-B in predicting MACE was significantly higher than that of single detection.According to ROC curve analysis,the area under the curve of combined detection of Hcy,BNP and VEGF-B level in predicting MACE was significantly higher than that of single detection.The cut off values of Hcy,BNP and VEGF-B for predicting MACE were 27.55μmol/L,22.39 pg/L and 55.29μg/L,respectively.Conclusion Hcy,BNP and VEGF-B are significantly correlated with the risk of MACE in STEMI,which could be used as an important basis for clinical evaluation in the future.