血清RBP4、visfatin、RIPK1水平在冠心病伴颈动脉粥样硬化患者中的表达及临床意义

目的 探究血清视黄醇结合蛋白4(RBP4)、内脏脂肪素(visfatin)、受体相互作用蛋白激酶1(RIPK1)水平在冠心病伴颈动脉粥样硬化(CAS)患者中的表达及临床意义。方法 选取2020年2月至2021年2月于该院就诊的163例冠心病患者作为研究对象，按是否伴CAS分为冠心病组79例和冠心病伴CAS组84例。同期选取72例于该院进行体检的体检健康者作为健康组，检测上述研究对象血清RBP4、visfatin、RIPK1水平并分析其与冠心病伴CAS组的相关性。结果 与健康组、冠心病组相比，冠心病伴CAS组血清RBP4、visfatin、RIPK1水平较高，差异有统计学意义(P<0.05)。与中度、轻度冠心病伴CAS患者相比，重度冠心病伴CAS患者血清RBP4、visfatin、RIPK1水平较高，差异有统计学意义(P<0.05);Pearson相关性分析显示，RBP4、Gensini评分呈正相关(r=0.429,P=0.001);RBP4、Gensini评分呈正相关(r=0.486,P=0.001);visfatin、Gensini评分呈正相关(r=0.630,P=0.0...

Expression and clinical significance of serum RBP4 ,visfatin,RIPK1 level in patients with coronary heart disease and carotid atherosclerosis

Objective To investigate the expression and clinical significance of serum retinol binding protein 4(RBP4),visfatin and receptor interacting protein kinase 1(RIPK1)levels in patients with coronary heart disease with carotid atherosclerosis(CAS).Methods Totally 163 patients with coronary heart disease treated in the hospital from February 2020 to February 2021 were selected as the research object.They were divided into 79 cases of coronary heart disease group and 84 cases of coronary heart disease with CAS group according to whether they were accompanied by CAS or not.In the same period,72 healthy people who underwent physical examination in the hospital were selected as the healthy group.The levels of serum RBP4,visfatin and RIPK1 were detected,and their correlation with CHD with CAS group was analyzed.Results Compared with healthy group and CHD group,serum RBP4,visfatin and RIPK1 levels were higher in CHD with CAS group,the difference was statistically significant(P<0.05).The levels of serum RBP4,visfatin and RIPK1 in severe CHD with CAS were higher than those in moderate and mild CHD with CAS,the differences were statistically significant(P<0.05).Pearson correlation analysis showed a positive correlation between RBP4 and Gensini scores(r=0.429,P=0.001).RBP4 and Gensini scores were positively correlated(r=0.486,P=0.001).visfatin and Gensini scores were positively correlated(r=0.630,P=0.001).RBP4 and Visfatin were positively correlated(r=0.364,P=0.001).RBP4 and RIPK1 were positively correlated(r=0.272,P=0.012).visfatin and RIPK1 were positively correlated(r=0.481,P=0.001).Conclusion Abnormally elevated levels of serum RBP4,visfatin and RIPK1 in CHD with CAS are independent risk factors for CHD with CAS.Early detection of serum RBP4,Visfatin and RIPK1 levels in patients with CHD with CAS are of positive significance for assessing the condition and guiding the treatment.