| microRNAs在脊髓损伤中的研究进展 |
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| 引用本文： | 景文,李生,李永盛,邱晓明. microRNAs在脊髓损伤中的研究进展[J]. 中国矫形外科杂志, 2022, 0(2): 145-148 |
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| 作者姓名： | 景文 李生 李永盛 邱晓明 |
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| 作者单位： | 定西市第二人民医院;兰州大学第二医院 |
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| 摘 要： | 脊髓损伤(spinal cord injury,SCI)的继发性病变如氧化应激、凋亡等会进一步加重神经功能损害.microRNAs(miRNAs)是一类新型的小非编码RNAs,其通过沉默翻译或干扰靶mRNAs的表达调控蛋白质的产生和细胞功能.SCI改变了氧化应激、炎症和凋亡等许多继发性损伤相关的miRNAs的表达.本综...
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| 关 键 词： | microRNAs 脊髓损伤 凋亡 氧化应激 |
Research progress of microRNAs in spinal cord injury |
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| JING Wen,LI Sheng,LI Yong-sheng,QIU Xiao-ming. Research progress of microRNAs in spinal cord injury[J]. Orthopedic Journal of China, 2022, 0(2): 145-148 |
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| Authors: | JING Wen LI Sheng LI Yong-sheng QIU Xiao-ming |
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| Affiliation: | (The Second People's Hospital of Dingxi City,Dingxi 743000,China;The Second Hospital,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Secondary lesions of spinal cord injury(SCI),such as oxidative stress and apoptosis,further aggravate the neurological impairment.The microRNAs(miRNAs)are a novel class of small non-coding RNAs that regulate protein production and cell function by silencing translation or interfering with the expression of target mRNAs.SCI alters the expression of miRNAs associated with many secondary injuries such as oxidative stress,inflammation and apoptosis.This review aims to clarify the latest research progress of miRNAs in apoptosis and oxidative stress secondary to spinal cord injury,and to provide a reference for further research of miRNAs in spinal cord injury. |
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| Keywords: | microRNAs spinal cord injury apoptosis oxidative stress |
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