| 褪黑素在椎间盘退变中的研究进展 |
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| 引用本文： | 王以典,郭旭东,康继贺,康学文. 褪黑素在椎间盘退变中的研究进展[J]. 中国矫形外科杂志, 2022, 0(1): 52-57 |
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| 作者姓名： | 王以典 郭旭东 康继贺 康学文 |
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| 作者单位： | 兰州大学第二医院骨科 |
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| 摘 要： | 椎间盘退变是下腰痛的主要因素之一,随着老年社会的到来,其发病率逐年升高,由于椎间盘退变(intervertebral disc degeneration,IDD)致病因素众多,其发病机制尚不清楚,目前仍无有效治疗药物.褪黑素(melatonin,MT)作为松果体分泌的一种神经内分泌激素,因其卓越的抗氧化应激、抗炎及抗细...
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| 关 键 词： | 椎间盘退变 褪黑素 炎症 凋亡 细胞外基质 |
Research progress of melatonin in intervertebral disc degeneration |
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| WANG Yi-dian,GUO Xu-dong,KANG Ji-he,KANG Xue-wen. Research progress of melatonin in intervertebral disc degeneration[J]. Orthopedic Journal of China, 2022, 0(1): 52-57 |
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| Authors: | WANG Yi-dian GUO Xu-dong KANG Ji-he KANG Xue-wen |
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| Affiliation: | (Department of Orthopaedics,The Second Hospital,Lanzhou University,Key Laboratory of Osteoarthritis of Gansu Province,Lanzhou 730030,China) |
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| Abstract: | Intervertebral disc degeneration(IDD)is one of the main reasons of low back pain.With the advent of the elderly society,its incidence is increasing year by year.Due to numerous pathogenic factors involving intervertebral disc degeneration,the pathogenesis is still unclear,and there is no effective drug for IDD.As a kind of neuroendocrine hormone secreted by pineal gland,melatonin(MT)has been widely studied in tumor,age-related degenerative diseases and so on because of its excellent anti-oxidation stress,anti-inflammatory and anti-apoptosis effects.This paper reviews the mechanism of MT to delay IDD and provides a reference for future research. |
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| Keywords: | intervertebral disc degeneration melatonin inflammation apoptosis extracellular matrix |
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