Amisulpride: efficacy in the management of chronic patients with predominant negative symptoms of schizophrenia |
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Authors: | Hans-Jürgen Möller |
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Institution: | (1) Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany, Tel.: +49-89/51 60 55 01, Fax: +49-89/51 60 55 22, E-Mail: hans-juergen.moeller@psy.med.uni-muenchen.de, DE |
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Abstract: | Amisulpride is a dopamine D2/D3-selective antipsychotic drug with potent antipsychotic efficacy in acute exacerbations of
schizophrenia. It also possesses substantial efficacy in chronic schizophrenic patients with enduring predominant negative
symptoms. This unique property has been demonstrated in a series of short (6 weeks) and medium-/long-term (6–12 months) double-blind
placebo-controlled studies. The patients in these studies were carefully selected and assessed to avoid confounding results
with non-specific changes in other symptom domains. The results not only show effects on negative symptoms at the optimal
dose of 100 mg/day, but also significant improvement in global functioning. The effect observed in short-term studies was
maintained over longer treatment periods (6–12 months). Amisulpride was well tolerated with a safety profile similar to placebo.
These results open a new therapeutic approach for negative symptoms, one of the most disabling aspects of schizophrenia.
Received: 25 July 2000 / Accepted: 26 July 2001 |
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Keywords: | Amisulpride Atypical antipsychotic Negative symptoms Placebo Schizophrenia |
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