Changes in the absorption of bile acids after total colectomy in patients with an ileostomy or pouch-anal anastomosis |
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Authors: | Mr D G Nasmyth MS FRCS D Johnston MD FRCS N S Williams MS FRCS R F G J King PhD L Burkinshaw PhD K Brooks |
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Institution: | (1) University Department of Surgery, The General Infirmary, Leeds, UK;(2) University Department of Medical Physics, The General Infirmary, Leeds, UK;(3) Present address: Surgical Unit, The London Hospital, London E1, UK;(4) Department of Surgery, Chester Royal Infirmary, St. Martin's Way, CH1 2AZ Chester, UK |
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Abstract: | Bile acid absorption was investigated using75Se Taurohomocholate (SeHCAT) in controls and patients who had undergone total colectomy with either conventional ileostomy
or pouch-anal anastomosis for ulcerative colitis or adenomatous polyposis. Whole-body retention of SeHCAT after 168 hours
was greater in the controls than the patients who had undergone colectomy (P<.05). Retention of SeHCAT did not differ significantly between patients with an ileostomy and patients with pouch-anal anastomosis,
but patients with an ileostomy and ileal resection of more than 20 cm retained less SeHCAT than patients with a pouch-anal
anastomosis (P<.01). Analysis of fecal bile acids from ileostomies and pouches showed that bacterial metabolism of primary conjugated bile
acids was greater in patients with a pouch. It was concluded that bile acid absorption was not significantly impaired by construction
of a pouch compared with conventional ileostomy but bacterial metabolism of bile acids was greater in the pouches.
Supported by a grant from the Yorkshire Regional Health Authority and was presented in part at the St. Mark's Hospital 150th
Anniversary International Conference, May 29 to 31, 1985. |
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Keywords: | Bile acids Ileostomy Pouch-anal anastomosis Colectomy Ulcerative colitis Adenomatous polyposis |
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