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目的研究妊娠晚期牙周炎孕妇龈沟液、唾液、血清中白介素-2（IL-2）含量变化以及三者间的关联。方法于2011年4—7月在湖北省妇幼保健院接受口腔检查的妊娠33～38周单胎孕妇中，随机选取20例牙周炎、26例牙龈炎、22例牙周健康孕妇（对照）纳入研究。分别采集其唾液、龈沟液和血清，采用双抗体夹心ELISA检测IL-2质量浓度。结果牙周炎组分娩时孕周（36．5周）明显小于牙龈炎组（38．8周）和对照组（39.3周），牙周炎组分娩时新生儿体重（3079．9g）低于牙龈炎组（3452．5g）和对照组（3462．4g），差异均有统计学意义（均P〈0．05）。牙周炎组大专及以上学历、孕前半年行口腔保健的比例明显低于牙龈炎组和对照组（均P〈0．05）。牙周炎组龈沟液、唾液中IL-2质量浓度明显高于牙龈炎组和正常对照组，差异有统计学意义（均P〈0．05）；但3组血清中IL-2质量浓度比较，差异无统计学意义（P〉0．05）。各组孕妇龈沟液、唾液、血清中IL-2质量浓度之间均两两呈线性相关，差异有统计学意义（均P〈0．01）。结论妊娠合并牙周炎孕妇口腔中IL-2含量较高，并与血清中IL-2质量浓度呈直线相关，在牙周炎合并不良妊娠结局（如早产、低体重儿等）的发病机制中起-定作用。重视口腔卫生是预防不良妊娠结局的方法之-。

Maternal periodontal inflammation and IL-2 levels of gingival crevicular fluid and saliva and serum in the third trimester

Objective To investigate the IL-2 levels of gingival crevicular fluid （GCF） and saliva and serum in peri-odontitis pregnancy women in the third trimenster and to find the associations among them. Methods Using the meth-ods of questionnaire and control study and based on the periodontal health status, totaly 68 pregnancy women in the third trimenster were divided into a periodontitis （PG, n = 20）, a gingivitis （GG, n = 26）, and a control group （CG, n = 22 ）. Fol-lowing pregnancy outcomes, data of those pregnancy women were obtained. GCF, saliva and serum were gathered, and the IL-2 levels were determined by ELISA. Results The childbirth weeks of gestation in PG （36.5 w） were significantly fewer than in GG（38.8 w） or in CG（39.3 w）, and the childbirth neonatal weight in PG（3079.9 g） was lower than in GG （3452.5 g） or in the CG （3462.4 g）. There were statistically significant differences （P 〈 0.05）. Statistically significant differences were observed：the IL-2 levels were higher in GCF and in saliva of PG than other groups （P 〈 0.01 ）, but no statistically significant differences of IL-2 levels in serum among those 3 groups. Statistically significant differences were observed： the levels of IL-2 in GCF, saliva, and serum were linearly correlated, respectively （P 〈 0.01 ）. Conclusion Periodontitis pregnancy women are evidently associated with increased GCF and saliva IL-2 level,which shows a corre- lation with maternal serum IL-2. The IL-2 levels play a certain role in periodontitis-related adverse pregnancy outcomes of preterm and preecalmpsia. Emphasis on oral hy- giene is one of the methods to prevent adverse preg- nancy outcomes.