| 智脑胶囊对阿尔茨海默病模型大鼠脑组织BDNF及其TrkB影响的实验研究 |
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| 引用本文： | 杨文明,周磊,孙林娟.智脑胶囊对阿尔茨海默病模型大鼠脑组织BDNF及其TrkB影响的实验研究[J].中国实验方剂学杂志,2010,16(3):68-70. |
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| 作者姓名： | 杨文明 周磊 孙林娟 |
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| 作者单位： | 1. 安徽中医学院第一附属医院神经内科,合肥,230031
2. 首都医科大学宣武医院神经内科,北京,100053 |
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| 基金项目： | 安徽省人才开发基金(2003Z026); 安徽省自然科学基金(99044591); 安徽省学科拔尖人才基金(教秘人[2006]112号); 安徽省重点学科基金(教高[2008]2号)资助 |
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| 摘 要： | 目的:观察智脑胶囊对实验性阿尔茨海默病(AD)模型大鼠脑组织脑源性神经营养因子(BDNF)及其酪氨酸蛋白激酶受体B(TrkB)的影响,探讨智脑胶囊治疗AD的作用机制。方法:雄性Wistar大鼠,随机分为7组,即正常对照组、假手术组、AD模型组、石杉碱甲组、智脑胶囊低、中、高剂量组。参照《大鼠脑立体定位图谱》,选双侧Meynert基底核为注射点,以鹅膏蕈氨酸(IBO)毁损双侧Meynert基底核,制作实验性AD大鼠模型。用ELISA酶联免疫法检测脑组织BDNF及其受体TrkB的含量,并观察其在大鼠脑组织皮层和海马不同部位含量的变化。结果:智脑胶囊能提高模型大鼠脑组织(皮层和海马)BDNF及其受体TrkB的含量,与模型组比较,差异有显著性(P0.05)。其中智脑胶囊高、中剂量组和石杉碱甲组的提高作用优于智脑胶囊低剂量组。结论:智脑胶囊促进大鼠脑组织皮层和海马神经元合成BDNF及其受体TrkB表达增加是其改善学习记忆的重要作用机制。
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| 关 键 词： | 阿尔茨海默病 智脑胶囊 脑源性神经营养因子 酪氨酸蛋白激酶受体B |
| 收稿时间： | 2/1/2009 12:00:00 AM |
Experimental Research of Effect on Brain-derived Neurotrophic Factors and Tyrosine Protein Kinase Receptors in the Tissue of Experimental Rat Model of Alzheimer's Disease Treated by Zhinao Capsule |
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| YANG Wen-ming,ZHOU Lei and SUN Lin-juan.Experimental Research of Effect on Brain-derived Neurotrophic Factors and Tyrosine Protein Kinase Receptors in the Tissue of Experimental Rat Model of Alzheimer's Disease Treated by Zhinao Capsule[J].China Journal of Experimental Traditional Medical Formulae,2010,16(3):68-70. |
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| Authors: | YANG Wen-ming ZHOU Lei and SUN Lin-juan |
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| Institution: | First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China;First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China;Xuanwu Hospital of the Capital University of the Medical Science, Bejing 100053, China |
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| Abstract: | Objective:To investigate the effect mechanism of Zhinao Capsule in treating Alzheimer disease and effect on brain-derived neurotrophic factors(BDNF) and tyrosine protein kinase receptors in the tissue of experimental rat model of Alzheimer's disease.Methods:Male Wistar rats were divided randomly into 7 groups:(1)normal group;(2)Sodium Chloride group;(3)model group;(4) huperzine A group;(5)low dose group of Zhinao Capsule;(6)middle dose group of Zhinao Capsule;(7) high dose group of Zhinao Capsule.According ... |
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| Keywords: | Alzheimer\'s disease Zhinao Capsule learning-memory ability brain-derived neurotrophic factors tyrosine protein kinase receptor B |
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