| 布托啡诺术后静脉镇痛对血浆5-羟色胺、P物质和肾上腺素的影响 |
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| 引用本文： | 钱卫,杜学柯,黄冰,孟志秀.布托啡诺术后静脉镇痛对血浆5-羟色胺、P物质和肾上腺素的影响[J].临床麻醉学杂志,2010,26(1). |
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| 作者姓名： | 钱卫 杜学柯 黄冰 孟志秀 |
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| 作者单位： | 广西医科大学肿瘤医院麻醉科,南宁市,530021 |
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| 基金项目： | 广西自然科学基金项目(项目编号:桂科自0640157) |
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| 摘 要： | 目的观察布托啡诺用于术后静脉自控镇痛对血清致痛物质5-羟色胺(5-HT)、P物质(PS)和肾上腺素(E)的影响。方法全麻手术患者30例随机均分为布托啡诺组(B组)、吗啡组(M组)和对照组(D组)。B组布托啡诺浓度0.006%,给药速率为0.0024 mg.kg-1.min-1,负荷剂量为0.005 mg/kg,每次有效按压给药0.003 mg/kg,锁定间隔时间10 min。M组吗啡浓度为0.025%,给药速率为0.005 mg.kg-1.min-1,负荷剂量为0.05 mg/kg,每次有效按压给药0.03 mg/kg,锁定间隔时间10 min。D组在患者需求时给予肌注吗啡10 mg。分别于麻醉诱导前(T0)、术后12 h(T1)、24 h(T2)、36 h(T3)、48 h(T4)采集肘静脉血3 ml,采用酶联免疫吸附测定法测定血清中5-HT、PS和E水平。结果B、M组T1~T4时5-HT、PS和E水平均低于D组(P<0.05)。结论布托啡诺静脉自控镇痛能抑制术后血清致痛物质5-HT、PS和E水平的升高,在一定程度上减弱痛觉信息传递,减轻机体应激反应。
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| 关 键 词： | 布托啡诺 静脉自控镇痛 5-羟色胺 P物质 肾上腺素 |
Effects of PCIA with butorphanol on 5-HT, P substance and epinephrine |
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| QIAN Wei,DU Xue-ke,HUANG Bing,et al..Effects of PCIA with butorphanol on 5-HT, P substance and epinephrine[J].The Journal of Clinical Anesthesiology,2010,26(1). |
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| Authors: | QIAN Wei DU Xue-ke HUANG Bing |
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| Institution: | QIAN Wei,DU Xue-ke,HUANG Bing,et al.Department of Anesthesiology Guangxi Tumor Instute,Nanning 530021,China |
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| Abstract: | Objective To study the effects of patient-controlled intravenous analgesia(PCIA) with butorphanol on plasma 5-Hydroxytryptamine(5-HT),P substance(PS),and epinephrine(E).Methods Thirty surgical patients were randomly divided into three groups with 10 cases each.PCIA with butorphanol was given in group B,with morphine in group D.The patients in group D were given morphine injection intramuscular when when needed.Venous blood samples were taken before anesthesia(T0),at 12 h(T1),24 h(T2),36 h(T3),and 48 h(T4)du... |
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| Keywords: | Butorphanol Patient-controlled intravenous analgesia 5-Hydroxytryptamine P substance Epinephrine |
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