| 156例维生素K_1注射液致严重不良反应分析 |
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| 引用本文： | 黄琳,李泮海,田月洁.156例维生素K_1注射液致严重不良反应分析[J].中国药房,2011(32):3047-3050. |
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| 作者姓名： | 黄琳 李泮海 田月洁 |
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| 作者单位： | 山东省药品不良反应监测中心; |
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| 摘 要： | 目的:为临床合理使用维生素K1注射液提供参考。方法:收集山东省药品不良反应监测中心数据库中2008-2010年间维生素K1注射液致严重不良反应的数据,并进行统计、分析;采用Instat软件,用χ2检验或确切概率法检验严重不良反应的影响因素。结果:共筛出严重不良反应156例,以呼吸系统损害、全身性损害为主,主要表现为呼吸困难、过敏样反应、紫绀、胸闷、过敏性休克、心悸、潮红等;维生素K1超适应证使用(P<0.0001)、维生素K1静脉给药(P=0.0024)和混合配伍用药(P=0.0001)可能增加严重不良反应发生的危险。结论:应重视和加强维生素K1注射液的合理使用,以减少其不良反应发生。
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| 关 键 词： | 维生素K1注射液 不良反应 影响因素 |
Analysis of 156 Cases of Serious Drug Adverse Reaction Induced by Vitamin-K_1 Injection |
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| HUANG Lin,LI Pan-hai,TIAN Yue-jie.Analysis of 156 Cases of Serious Drug Adverse Reaction Induced by Vitamin-K_1 Injection[J].China Pharmacy,2011(32):3047-3050. |
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| Authors: | HUANG Lin LI Pan-hai TIAN Yue-jie |
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| Institution: | HUANG Lin,LI Pan-hai,TIAN Yue-jie(Shandong Center for ADR Monitoring,Jinan 250013,China) |
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| Abstract: | OBJECTIVE:To provide reference for clinical rational use of Vitamin-K1 injection. METHODS: Serious drug adverse reactions induced by Vitamin-K1 injection were statistical analyzed from 2008 to 2010 in Shandong Center for ADR Monitoring. Chi-square test or Fisher's exact test tests detected the influencing factors of serious adverse drug reactions using Instat software. RESULTS: There were 156 serious adverse drug reactions, they were systemic damage and respiratory damage. The main manifestations were dyspn... |
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| Keywords: | Vitamin-K1 injection Adverse drug reactions Influencing factors |
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