尼尔雌醇联合盐酸氟西汀治疗绝经期妇女抑郁症的疗效观察

目的:观察尼尔雌醇联合盐酸氟西汀治疗绝经期妇女抑郁症的疗效。方法:将147例绝经期抑郁症妇女随机分为3组,联合组50例,给予尼尔雌醇,每2周1次,每次1mg,同时每日晨服盐酸氟西汀,每次20mg;尼尔雌醇组50例,给予尼尔雌醇每2周1次,每次1mg;氟西汀组47例,每日晨服盐酸氟西汀,每次20mg。3组疗程均为12周。采用Hamilton抑郁量表(HAMD)评价抑郁严重程度,采用Kupperman评分指数(KMI)评价绝经期症状。结果:治疗后3组HAMD总分均下降,差异有统计学意义(P<0.001),联用组比尼尔雌醇组下降明显,差异有统计学意义(P<0.01)。治疗后3组KMI评分指数总分均下降,差异有统计学意义(P<0.01),但联用组和尼尔雌醇组与氟西汀组比较减分率更高,差异有统计学意义(P<0.01)。3组均未见严重不良反应发生。结论:尼尔雌醇联合盐酸氟西汀治疗发生于绝经期的抑郁症,可以显著提高疗效,且副作用小。

Efficacy Observation of Hydrochloride in the Treatment of Menopausal Depression

OBJECTIVE:To observe the therapeutic efficacy of nilestriol combined with fluoxetine hydrochloride in the treatment of menopausal depression. METHODS: 147 female with menopausal depression were randomly divided into 3 groups. 50 cases in combination group received nilestriol 1 mg once every 2 weeks and fluoxetine hydrochloride 20 mg once a day in the morning. 50 cases in nilestriol group received nilestriol 1 mg once every 2 weeks. 47 cases in fluoxetine group received fluoxetine 20 mg once a day in the mor...