红霉素联合多潘立酮治疗胰头癌PD术后功能性胃排空障碍的疗效观察

目的:观察红霉素联合多潘立酮混悬液治疗功能性胃排空障碍的疗效。方法:将45例患者随机分成2组,均用胃管注入多潘立酮混悬液,静脉补液维持水、电解质平衡及补充营养物质;治疗组在此基础上加用红霉素6～8mg·kg-1·d-1,分2次加入5%葡萄糖液250mL,早晚静脉滴注,连用21d。结果:治疗21d后治疗组有效率为91.3%,对照组为63.6%,2组比较差异有统计学意义(P<0.05)。2组不良反应均较轻微。结论:红霉素联合多潘立酮混悬液治疗胰头癌PD术后功能性胃排空障碍有较好的临床疗效且不良反应轻微。

Efficacy Observation of Erythromycin Combined with Domperidone in the Treatment of Functional Delayed Gastric Emptying after PD Surgery for Pancreatic Head Cancer

OBJECTIVE：To observe the clinical efficacy of erythromycin combined with Domperidone suspension in the treatment of functional delayed gastric emptying. METHODS： 45 patients were randomly divided into 2 groups. 2 groups received Domperidone suspension by gavage of gastric tube, intravenous fluids to maintain water and electrolyte balance and added nutrients; treatment group additionally received erythromycin 6～8 mg·kg-1·d-1 with 5% glucose solution 250 mL added twice a day, morning and night, intravenous infusion for 21 d. RESULTS： The effective rate of treatment group was 91.3% and that of control group was 63.6% after 21 d, the difference of effective rate of 2 groups had statistical significance（P0.05）. ADR of 2 groups were mild. CONCLUSION： Erythromycin combined with Domperidone suspension is effective against functional delayed gastric emptying after PD surgery for pancreatic head cancer in the clinical practice.