人工泪液与重组人表皮生长因子衍生物眼液对翼状胬肉术后干眼疗效观察

目的 探讨人工泪液联合重组表皮生长因子衍生物滴眼液治疗翼状胬肉术后干眼的疗效.方法 选择翼状胬肉术后有干眼症状的患者82例(96只眼),随机分为治疗组和对照组两组,每组41例(48只眼),治疗组给予人工泪液(泪然)和重组表皮生长因子衍生物(金因舒)治疗,对照组单用人工泪液,裂隙灯下观察,记录用药前及用药后2周、4周泪膜破裂时间(BUT),泪液分泌实验(schimer-1),角膜荧光素染色(FL)以及干眼症状的改善程度.结果 治疗前,治疗组与对照组Schirmer-1、BUT、FL差异无统计学意义(P>0.05);用药后2周、4周,治疗组schimer-1、BUT、FL以及临床症状的改善与对照组比较,差异有统计学意义(P<0.01).结论 人工泪液联合重组表皮生长因子衍生物滴眼液治疗翼状胬肉术后干眼疗效优于单用人工泪液,效果显著.

The effect of artificial tears and Recombinant human epidermal growth factor on dry eye after pterygum excision

Objective To discuss the clinical curative effects of artificial tears and recombinant human epidermal growth factor (rhEGF) on dry eye after pterygum excision.Methods All 82 examples(96 eyes)with dry eye symptom after the excision of pterygum were chosen and randomly divided into two groups,the treatment group and control group.In the treatment group,the patients were treated by rhEGF and artificial tears eyedrops.In the control group,the patients were only treated by artificial tears.The subjective dry eye Symptoms,fluorescein staining(FL),the time of tear secretion (Schirmers test Ⅰ)and tear break-up time (BUT) were observed by the slit lamp before treatment,the second and the forth week after treatment.Results There was no statistical difference between the two groups before treatment (P>0.05).After treatment,the subjective dry eye Symptoms,FL,Schirmers test Ⅰ and BUT were significantly different (P<0.01).Conclusions Artificial tears combined with rhEGF eyedrops can be effective to relieve the dry eye symptoms after pterygum excision.