| 3,4—二氯苯丙烯酰另丁胺抗抑郁作用的药理研究 |
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| 引用本文： | 李树新,库宝善.3,4—二氯苯丙烯酰另丁胺抗抑郁作用的药理研究[J].中国药理学通报,1991(4). |
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| 作者姓名： | 李树新 库宝善 |
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| 作者单位： | 北京医科大学药理教研室 北京100083
(李树新)，北京医科大学药理教研室 北京100083(库宝善) |
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| 摘 要： | 研究一种新的胡椒碱衍化物:3,4—二氯苯丙烯酰另丁胺(7903)对五种抑郁动物模型的影响。7903在小于TD_(50)剂量下,对所用动物模型均显示出抗抑郁效应,即在不增加动物的自主活动情况下,急性ip 7903可明显缩短小鼠及大鼠强迫游泳不动状态时间;急性ip或po明显缩短小鼠悬尾不动时间;慢性(二周)ip可明显缩短电刺激小鼠角膜引起的最长持续不动状态时间;急性ip可明显改善利血平引起的小鼠体温下降。
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| 关 键 词： | 抗抑郁药 胡椒碱衍化物 悬尾实验 强迫游泳实验 利血平降温实验 |
THE PHARMACOLOGICOL STUDY ABOUT ANTIDEPRESSANT EFFECTS OF THE 7903 |
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| Li Shuxin,Ku Baoshan.THE PHARMACOLOGICOL STUDY ABOUT ANTIDEPRESSANT EFFECTS OF THE 7903[J].Chinese Pharmacological Bulletin,1991(4). |
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| Authors: | Li Shuxin Ku Baoshan |
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| Abstract: | The antidepressant effects of the N-Isosuccinyl-dichlorocinnamo-ylamide ( 7903 ) , an analogue of piperine, upon 5 animal models were studied. The 7903 was found to have antidepressant effects on the models with doses less than TD50. The 7903 with the single dose, which did not increase the spontaneous motor activity of animals, could significantly decrease the duration of immobility of mice and rats in the forced-swimming test and that of mice in the tail-suspension test. The duration of the longest permanent immobility indaced by cornea electro-stimulation in mice was also decreased with the chronic administration ( 2 weeks ) of the 7903. And the hypothermia induced by reserpine could be antagonized by the 7903. |
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| Keywords: | Antidepressants Analogue of piperine Tail-suspension test Forced-swimming test Hypothermia induced by reserpine |
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