OKT4+ T cell deficiency and an association of immunoglobulin deficiency in systemic lupus erythematosus. |
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| Authors: | S Raziuddin and B H Danial |
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| Affiliation: | Department of Immunology, King Saud University, College of Medicine, Abha, Saudi Arabia. |
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| Abstract: | A patient with systemic lupus erythematosus and selective serum IgA and IgM deficiency also had a deficiency of OKT4+, OKT4A+, OKT4B+, and OKT4E+ T cells in circulating blood. This deficiency of helper/inducer T cell subsets in blood was associated with impaired T cell responses to phytohaemagglutinin in vitro, and an impaired ability to produce IgA and IgM by the patient's B cells. The patient's OKT4+ (CD4+) T cell deficient population suppressed IgM synthesis by normal B and T cells. |
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