Comparisons of clinical features of HLA‐DRB1*07 positive and negative vitiligo patients in Chinese Han population |
| |
| Authors: | D‐Y Hu Y‐Q Ren K‐J Zhu Y‐M Lv H Cheng Z Zhang Y Li S‐M He J Tang J‐L Liu Y Lin Y‐Y Sun X‐B Zuo G Chen L‐D Sun S Yang X‐J Zhang |
| |
| Institution: | 1. Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui, China;2. State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Anhui, China |
| |
| Abstract: | Background Human leucocyte antigen (HLA)‐II alleles have been found to be associated with vitiligo in different populations, and several studies also suggested that HLA class II alleles/haplotypes were associated with a different type vitiligo. Of HLA class II alleles, DRB1*07 has consistently shown a positive association with vitiligo in Chinese Han population. Objective To further explore the relationship between DRB1*07 and vitiligo and to evaluate the DRB1*07 effect on the clinical features of vitiligo in Chinese Han population. Methods This study investigated DRB1*07 allele distribution in 1178 unrelated Chinese vitiligo patients and 1743 healthy controls using polymerase chain reaction/sequence specific primer method and observed clinical differences between DRB1*07 positive and DRB1*07 negative patients. Results The analysis of the 1178 cases and 1743 controls revealed a highly association between DRB1*07 allele and vitiligo odds ratio (OR) = 1.97, P = 2.13 × 10?17]. DRB1*07 positive patients had early disease onset (OR = 1.49, P = 0.001), higher frequency of family history (OR = 1.44, P = 0.006) compared with DRB1*07 negative patients. Conclusions The DRB1*07 showed significant association with vitiligo in the study population. This study confirmed that DRB1*07 positive patients had some obvious clinical differences from DRB1*07 negative patients in the Chinese Han population. |
| |
| Keywords: | association HLA‐DRB1*07 vitiligo |
|
|
