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帕金森病分子病理机制研究进展
作者姓名:张娜  窦德强
作者单位:辽宁中医药大学药学院,大连,116600,中国
基金项目:辽宁省高等学校创新团队课题(LT2013020)
摘    要:帕金森病(Parkinson's disease,PD)是一种中老年常见的神经系统退行性疾病,PD的主要病理特点是黑质致密部的多巴胺能神经元丢失,进而使纹状体内的多巴胺水平降低。目前,PD的发病原因尚不完全清楚,本文从遗传因素、环境因素、线粒体功能障碍、氧化应激、氮化应激、免疫炎性反应异常、细胞凋亡学说和神经递质失衡等方面系统总结了近年来PD的病理机制,深入了解 PD 发病机制,为PD的进一步研究提供理论依据。

关 键 词:帕金森  分子水平  病理机制  

Advances in the Molecular Pathogenesis of Parkinson's Disease
Authors:ZHANG Na  DOU De-qiang
Institution:College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116600,Liaoning,China
Abstract:Parkinson's disease is a common degenerative disease of the nervous system in elderly people. The main pathological features of Parkinson's substantia nigra is the disappearance of dopamine neurons, which reduces the dopamine level in the striatum. This paper summarized the pathogenesis of Parkinson's disease in recent years in several aspects, including genetic factors, environmental factors, mitochondrial dysfunction, oxidative stress, nitrogen stress, abnormal immune inflammatory response, apoptosis doctrine and neurotransmitter imbalances. This review provides a theoretical basis for further study of Parkinson's disease.
Keywords:Parkinson  Molecular level  Pathological mechanisms  
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