药物滥用性头痛患者认知功能及事件相关电位P300的研究

目的探讨药物滥用性头痛(MOH)患者认知功能及认知电位的变化情况。 方法MOH患者(观察组)及对照组各30例，两组均进行P300、简易精神状态量表(MMSE)检测。采用SPSS 10.0软件进行数据处理，P300潜伏期、波幅比较采用t检验。 结果两组P300靶刺激中P3潜伏期、波幅比较均差异有统计学意义：观察组P3潜伏期分别为(393.70±42.60)ms]较对照组(331.05±22.35)ms]延长，差异有统计学意义(t＝7.13，P<0.05)；观察组P3波幅(3.40±2.30)uV]较对照组(6.20±2.40)uV]明显降低，差异也有统计学意义(t＝4.59，P<0.05)。两组MMSE评分比较，观察组总分、定向力、记忆力、计算力、回忆力、语言能力(24.00±2.21)分，(8.15±0.86)分，(2.88±0.23)分，(3.07±1.04 )分，(1.72±0.89)分，(8.42±1.33)分]低于对照组分别为(27.07±2.06)分，(9.28±1.03)分，(3.01±0.26)分，(3.25±1.20)分，(1.92±0.90)分，(9.69±1.44)分]，总分、定向力、语言能力评分差异有统计学意义(t＝3.66，3.19，3.34；P<0.05)。 结论MOH患者存在轻度的认知功能障碍，认知电位P300为MOH患者认知功能障碍的诊断提供一客观指标。

Clinical research of the cognitive function and event-related potential P300 in patients with medication-overuse headache

ObjectivesTo explore the changes of cognitive function and potential in patients with medication-overuse headache (MOH). MethodsThe subjects were divided into two groups: observation group (patients with MOH, n=30) and control group (n=30). P300 was used to detect the cognitive potential and mini mental state examination (MMSE) was performed to evaluate the cognitive function of the subjects. ResultsThe differences between the two groups were significant.The P3 latency in observation group (393.70±42.60) ms] was more prolonged than that in the control group (331.05±22.35) ms]. The difference between the two groups was significant(t=7.13, P<0.05); The amplitudes of P3 in observation group (3.40±2.30)uV], was lower than that in the control group (6.20±2.40)uV]. The difference between the two groups was also significant(t=4.59, P<0.05). The MMSE in observation group were shown as follows: total score (24.00±2.21), orientation (8.15±0.86), anamnesis (2.88±0.23), calculation (3.07±1.04), recall (1.72±0.89) and language (8.42±1.33). In control group, the MMSE were shown as total score (27.07±2.06), orientation (9.28±1.03), anamnesis (3.01±0.26), calculation (3.25±1.20), recall (1.92±0.90) and language (9.69±1.44). The differences between the two groups were all significant (t=3.66, 3.19, 3.34, P<0.01). ConclusionThe patients with MOH had the mild cognitive impairment, and P300 cognitive potential could provide objective indicators for the diagnosis of cognitive dysfunction of patients with MOH.