AQP-5在结直肠癌中的表达及意义

目的探讨结直肠癌组织中AQP-5的表达情况及其与肿瘤分化程度的关系。 方法收集48例结直肠癌病变的石蜡包埋标本(结肠癌17例，直肠癌31例)，采用免疫组织化学S-P方法检测AQP-5在上述病变组织中的表达。 结果结肠癌组织中癌细胞AQP-5(＋)表达率为64.7%(11/17)，其中高、中分化癌组织病例中，呈阳性者3例，阳性率为33.3%，而8例低分化病例中，阳性8例，阳性率为100.0%，二者表达差异显著(P<0.01)。直肠癌病变中癌细胞AQP-5(＋)表达率为70.9%(22/31)，13例高中分化病例中，阳性者6例，阳性率46.2%，18例低分化病例中16例呈阳性，阳性率为88.8%，二者具有差异(P<0.05)；两种类型肠癌CD10表达无统计学差异(P>0.05)。 结论AQP-5有助于显示结直肠癌的分化程度，对选择治疗方案及判断预后有一定意义。

Expression and role of AQP-5 in colorectal cancer

ObjectiveTo analyze the expression of AQP-5 in colorectal carcinoma, and to explore the relationship between AQP-5 expression and differentiation of the tumor. Methods48 cases of colorectal carcinoma samples were collected, including 17 cases of colon carcinoma and 31 cases of rectum carcinoma.Expression of AQP-5 was detected by immunohistochemical s-p method. ResultsThe positive expression rate of AQP-5 of carcinoma cells in colon carcinoma was 64.7%(11/17). In well-and moderately-differentiated carcinoma groups, the positive expression rate was 33.3%(3/9), however, that in poorly carcinoma was 100.0%(8/8), which showed difference between two groups(P<0.01). The positive expression rate of AQP-5 of carcinoma cells in rectum carcinoma was 70.9%(22/31). In well-and moderately-differentiated carcinoma groups, AQP-5 was expressed in 6 cases, with a positive rate of 46.2%, that in poorly carcinoma was 88.8%(16/18), there was statistically difference(P<0.05); AQP-5 expression was not different in two types of carcinoma(P>0.05). ConclusionAQP-5 seems to be a highly effective marker for differentiation in colon and rectum carcinoma, it may be very helpful to make the best choice of treatment and prognosis.