| 咪唑啉I2受体神经药理学研究进展 |
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| 引用本文： | 邱艳艳,李俊旭,何小华. 咪唑啉I2受体神经药理学研究进展[J]. 神经药理学报, 2013, 3(1): 48 |
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| 作者姓名： | 邱艳艳 李俊旭 何小华 |
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| 作者单位： | 1. 纽约州立大学布法罗分校药理学和毒理学系，布法罗，14214，美国2．武汉大学基础医学院病理学与病理生理学系，武汉，430071，中国 |
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| 基金项目： | 美国国立卫生研究院NIH (1R01DA034806, 1R21DA033426) |
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| 摘 要： | 咪唑啉I2受体是一种非G蛋白偶联受体，其生理功能及临床意义目前尚不十分清楚。近年大量研究表明I2受体通过相关配体介导多种行为学效应。激活咪唑啉I2受体可能产生镇痛、抗抑郁、调节阿片受体功能、神经元保护等多种药理学作用。本文着重介绍了I2受体的分布、细胞定位、分子结构、信号转导、内源性配体和选择性配体及其相关神经药理学效应的研究进展。
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| 关 键 词： | 咪唑啉I2受体 配体 神经药理学 |
The Neuropharmacology of Imiazoline-I2 Receptors |
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| QIU Yan-yan,LI Jun-xu,HE Xiao-hua. The Neuropharmacology of Imiazoline-I2 Receptors[J]. Journal of Hebei North University(Medical Edition), 2013, 3(1): 48 |
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| Authors: | QIU Yan-yan LI Jun-xu HE Xiao-hua |
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| Affiliation: | 1. Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, 14214, USA 2. Department of Pathophysiology, School of Medicine, Wuhan University, Wuhan, 430071, China |
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| Abstract: | Imidazoline-I2 receptor is a group of non-G protein-coupled receptors (GPCR). Its physiological function and clinical significance remains elusive. Accumulating evidence has implicated the imidazoline-I2 receptors in a wide range of behavioral effects, including analgesia, antidepressant-like effects, modulation of μ opioid receptors and neuroprotection. Here, we provided an updated overview of its location, molecular structure, signal transduction, endogenous ligands, synthetic ligands and related neuropharmacological effects. |
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| Keywords: | imidazoline-I2 receptor ligand neuropharmacology |
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