糖尿病患者干眼症发病因素分析

目的：探讨多种眼表因素异常在糖尿病干眼症发病中的作用。方法：对107例汉族（乌鲁木齐市）2型糖尿病患者存在的干眼症状及有关的眼表因素（泪液基础分泌、泪膜稳定性、泪液性状、角膜上皮完整性）检查结果量化后进行单因素及多因素的非条件Logistic回归分析。结果：泪膜稳定性下降（P=0．020，OR=12．268），泪液基础分泌量减少（P=0．007，OR=5．398），与糖尿病人干眼症发生呈显著正相关，差异有统计学意义。结论：泪膜稳定性下降、泪液基础分泌量减少在汉族2型糖尿病患者干眼症的发病中起一定作用。

The analysis of the pathogeny of dry-eye in type 2 diabetic patients

Objective: To explore the relationship between multivariate ocular factors and the development of dry eye in type 2 diabetes mellitus. Methods: One hundred and six cases with type 2 diabetes mellitus were selected and evaluated with a series of ocular testing of the Schirmer I, the tears film stability, the staining with fluorescein sodium on cornea and the tears ferning. A questionnaire about dry eye was surveyed. One-way and multivariate non-conditional logistic regression analysis were used to analyze the relation between multivariate ocular factors and the development of dry eye in type 2 diabetes mellitus. Results: The unstable tears flilm (P=0.020, OR=12.268) and the decrease of basal tears secretion (P=0.007, OR=(5.398))had positive relationship with the development of dry eye in type 2 diabetes mellitus. Conclusion: Our date showed that the unstable tear flilm and the decrease of basal tears secretion might play a role in the development of dry eye in type 2 diabetes mellitus.