| 硝酸甘油静脉滴注对家兔急性心肌梗塞后室颤阈演变的影响 |
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| 引用本文： | 邓春玲,汤宁,李光泽.硝酸甘油静脉滴注对家兔急性心肌梗塞后室颤阈演变的影响[J].郑州大学学报(医学版),1987(4). |
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| 作者姓名： | 邓春玲 汤宁 李光泽 |
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| 作者单位： | 河南医科大学病理生理教研室
(邓春玲，汤宁)，河南医科大学病理生理教研室(李光泽) |
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| 摘 要： | 在观察家兔左室支结扎后两小时内室颤阈(VFT)自然演变规律基础上,观察研究了硝酸甘油(NTG)静脉滴注对家兔急性心肌梗塞后VFT演变的影响。结果表明:NTG并未减轻因急性心肌缺血而导致的VFT下降程度,但持续NTG静脉滴注可使左室支结扎后两小时内VFT的恢复明显加速,并使恢复最大值提高。提示NTG有助于改善缺血心肌的血液灌流,降低心电不稳定性,因而具有潜在的抗心律失常作用,10%葡萄糖可部分抵销NTG的这一作用。
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| 关 键 词： | 急性心肌梗塞 室颤阈 硝酸甘油 |
The effect of intravenous infusion of the dynamic changes of ventricular fibrillation threshold (VFT) after acute myocardial ischemia in rabbits |
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| Deng Chunling et al.The effect of intravenous infusion of the dynamic changes of ventricular fibrillation threshold (VFT) after acute myocardial ischemia in rabbits[J].Journal of Zhengzhou University: Med Sci,1987(4). |
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| Authors: | Deng Chunling |
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| Institution: | Deng Chunling et al Department of Pathophysiology,Henan Medical University |
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| Abstract: | On the basis of the law of natural change of VFT during the period of two hours after theecclusion of the left ventricular branch(LVB),observation and research were made on the effectof intravenous infusion of nitroglycerin on the dynamic changes of VFT after acute myocardialischemia in rabbits. The results showed that NTG failed to alleviate the reduction of VFT dueto myocardial ischemia immediately after the occlusion of LVB, but persisting infusion of NTGcould promote the recovery of VFT during the period of 120 min after lusion. This indicatesthat NTG has a benificial effect on reducing the unstability of the electrophysiologic acti-vity of the ischemic myocardium. Thus, it possesses a potential effect of antiarrhythmia.10% glucose can partly counteract the effect of this activity. |
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| Keywords: | acute myocardial ischemia (AMT) ventricular fibrillation threshold(VFT) nitroglycerin (NTG) |
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