| Human microbiome is a diagnostic biomarker in hepatocellular carcinoma |
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| 作者姓名： | Ben-Chen Rao Jia-Min Lou Wei-Jie Wang Ang Li Guang-Ying Cui Zu-Jiang Yu Zhi-Gang Ren |
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| 作者单位： | Department of Infectious Diseases;Gene Hospital of Henan Province;Department of Hepatobiliary and Pancreatic Surgery |
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| 基金项目： | supported by grants from the National Key Research and Development Program of China(2018YFC2000501);National Natural Science Foundation of China(81600506);National S&T Major Project of China(2018ZX10301201-008);China Postdoctoral Science Foundation(2017M610463 and 2018M632814). |
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| 摘 要： | Background:Hepatocellular carcinoma(HCC)is the third leading cause of cancer mortality worldwide.Increasing evidence indicates a close relationship between HCC and the human microbiota.Herein,we reviewed the important potential of the human microbiota as a diagnostic biomarker of HCC.Data sources:Several innovative studies have investigated the characteristics of the gut and oral micro-biomes in patients with HCC and proposed that the human microbiome has the potential to be a diag-nostic biomarker of HCC.Literature from February 1999 to February 2019 was searched in the PubMed database using the keywords"microbiota"or"microbiome"or"microbe"and"liver cancer"or"hepato-cellular carcinoma",and the results of clinical and experimental studies were analyzed.Results:Specific changes occur in the human microbiome of patients with HCC.Moreover,the gut mi-crobiome and oral microbiome can be used as non-invasive diagnostic biomarkers for HCC.Furthermore,they also have certain diagnostic potential for precancerous diseases of HCC.The diagnostic potential of the blood microbiota and ascites microbiota in HCC will be gradually discovered in the future.Conclusions:The human microbiome is valuable to the diagnosis of HCC and provides a novel strategy for targeted therapy of HCC.The human microbiome may be widely used in the diagnosis,treatment and prognosis for multiple system diseases or cancers in the future.
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| 关 键 词： | Human MICROBIOME GUT MICROBIOME ORAL MICROBIOME HEPATOCELLULAR carcinoma DIAGNOSTIC BIOMARKER |
| 收稿时间： | 21 June 2019 |
Human microbiome is a diagnostic biomarker in hepatocellular carcinoma |
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| Ben-Chen Rao,Jia-Min Lou,Wei-Jie Wang,Ang Li,Guang-Ying Cui,Zu-Jiang Yu,Zhi-Gang Ren.Human microbiome is a diagnostic biomarker in hepatocellular carcinoma[J].Hepatobiliary & pancreatic diseases international : HBPD INT,2020,19(2):109-115. |
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| Institution: | 1. Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;2. Gene Hospital of Henan Province; Precision Medicine Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;3. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;1. School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;2. Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China;3. International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China;4. National Center for Liver Cancer, Shanghai 201805, China;5. Biliary Tract Department II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;6. Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;7. Biliary Tract Department I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;8. Department of Special Medical Care & Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;9. Department of Oncology, Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China;1. Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;2. Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;3. Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;4. Department of Imaging, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;1. HPB Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK;2. Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK;3. Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TH, UK;1. Department of Minimally Invasive Digestive Surgery, Antoine-Beclere Hospital, AP-HP, Clamart F-92140, France;2. Paris-Saclay University, Orsay F-91405, France;3. Department of Radiology, Antoine-Beclere Hospital, AP-HP, Clamart F-92140, France;4. Department of Intensive Care Unit, Antoine-Beclere Hospital, AP-HP, Clamart F-92140, France |
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| Abstract: | Background: Hepatocellular carcinoma(HCC) is the third leading cause of cancer mortality worldwide. Increasing evidence indicates a close relationship between HCC and the human microbiota. Herein, we reviewed the important potential of the human microbiota as a diagnostic biomarker of HCC. Data sources: Several innovative studies have investigated the characteristics of the gut and oral microbiomes in patients with HCC and proposed that the human microbiome has the potential to be a diagnostic biomarker of HCC. Literature from February 1999 to February 2019 was searched in the Pub Med database using the keywords "microbiota" or "microbiome" or "microbe" and "liver cancer" or "hepatocellular carcinoma", and the results of clinical and experimental studies were analyzed. Results: Specific changes occur in the human microbiome of patients with HCC. Moreover, the gut microbiome and oral microbiome can be used as non-invasive diagnostic biomarkers for HCC. Furthermore, they also have certain diagnostic potential for precancerous diseases of HCC. The diagnostic potential of the blood microbiota and ascites microbiota in HCC will be gradually discovered in the future. Conclusions: The human microbiome is valuable to the diagnosis of HCC and provides a novel strategy for targeted therapy of HCC. The human microbiome may be widely used in the diagnosis, treatment and prognosis for multiple system diseases or cancers in the future. |
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