SARS-CoV-2 Period Seroprevalence and Related Factors,Hillsborough County,Florida, USA,October 2020–March 2021 |
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Authors: | Anna R Giuliano Shari Pilon-Thomas Michael J Schell Martha Abrahamsen Jessica Y Islam Kimberly Isaacs-Soriano Kayoko Kennedy Christopher W Dukes Junmin Whiting Julie Rathwell Jonathan A Hensel Leslie N Mangual Ernst Schonbrunn Melissa Bikowitz Dylan Grassie Yan Yang |
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Institution: | Moffitt Cancer Center, Tampa, Florida, USA (A.R. Giuliano, S. Pilon-Thomas, M.J. Schell, M. Abrahamsen, J.Y. Islam, K. Isaacs-Soriano, K. Kennedy, C.W. Dukes, J. Whiting, J. Rathwell, J.A. Hensel, L.N. Mangual, E. Schonbrunn, D. Grassie, Y. Yang);University of South Florida Morsani College of Medicine, Tampa (M. Bikowitz) |
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Abstract: | Estimating the actual extent of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is challenging because virus test positivity data undercount the actual number and proportion of persons infected. SARS-CoV-2 seroprevalence is a marker of past SARS-CoV-2 infection regardless of presence or severity of symptoms and therefore is a robust biomarker of infection period prevalence. We estimated SARS-CoV-2 seroprevalence among residents of Hillsborough County, Florida, USA, to determine factors independently associated with SARS-CoV-2 antibody status overall and among asymptomatic antibody-positive persons. Among 867 participants, SARS-CoV-2 period prevalence (October 2020–March 2021) was 19.5% (asymptomatic seroprevalence was 8%). Seroprevalence was 2-fold higher than reported SARS-CoV-2 virus test positivity. Factors related to social distancing (e.g., essential worker status, not practicing social distancing, contact with a virus-positive person, and length of contact exposure time) were consistently associated with seroprevalence but did not differ by time since suspected or known infection (<6 months vs. >6 months). |
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Keywords: | COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections zoonoses vaccine-preventable diseases serosurvey seroprevalence seroepidemiologic studies Hillsborough County Florida United States |
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