| 红霉素链霉菌抗噬菌体菌株的选育 |
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| 引用本文： | 曹文伟,张德民,赵正权. 红霉素链霉菌抗噬菌体菌株的选育[J]. 中国抗生素杂志, 1993, 0(6) |
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| 作者姓名： | 曹文伟 张德民 赵正权 |
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| 作者单位： | 辽宁师范大学生物系 大连116022(曹文伟，张德民)，大连制药厂 大连116022(赵正权) |
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| 摘 要： | 以红霉素链霉菌(Streptomyces erythreus)Dm65为出发菌株,经紫外线诱变处理,采用不接触噬菌体的影印方法,筛选到1株抗11种噬菌体的高产菌株。通过噬菌体的侵染试验和摇瓶发酵试验证明:其对11种噬菌体的抗性十分稳定;红霉素的发酵效价比对照菌株提高44％。该菌株在红霉素生产中投入使用后,有效地控制了噬菌体的污染。
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| 关 键 词： | 红霉素链霉菌 噬菌体 抗噬菌体菌株 |
THE SCREENING OF PHAGE-RESISTANT STRAIN OF STREPTOMYCES ERYTHREUS |
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| Cao Wan-wei and Zhang De-min. THE SCREENING OF PHAGE-RESISTANT STRAIN OF STREPTOMYCES ERYTHREUS[J]. Chinese Journal of Antibiotics, 1993, 0(6) |
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| Authors: | Cao Wan-wei and Zhang De-min |
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| Abstract: | Streptomyces erythreus Dm65 was treated as a starting strain by UV radiation and a high-production strain that resisted 11 strains of phages was screened out by replica plating method in which phages were not contacted. Both infecting-test and shaking-flask fermentation test show that the screened strain had steady resistance to 11 strains of phages and the production of Erythromycin increased by 44% than Dm65.By using of this phage-resistant strain in large scale production could efficiently control the contaminating of phages. |
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| Keywords: | Streptomyces erythreus Phage Phage-resistant strain |
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