硝苯地平缓释片致牙龈增生

患者男,45岁。因患原发性高血压口服硝苯地平片5mg,3次/d,6年中未出现不良反应。后改服硝苯地平缓释片10mg,2次/d。1年后,出现牙龈增生,伴出血、疼痛,经罗红霉素、甲硝唑芬布芬胶囊治疗未见好转。怀疑与硝苯地平缓释片有关,遂改服贝那普利、美托洛尔,1个月后患者牙龈增生现象消失。之后患者因血压未能稳定控制而再次服用硝苯地平缓释片5mg,2次/d,2个月后又出现牙龈增生,再次停药,1个月后增生消失。

Gingival hyperplasia caused by nifedipine sustained-release tablets

A 45-year-old man with primary hypertension took nifedipine tablets 5 mg thrice daily for 6 years.And no adverse reactions were found.Later,he received nifedipine sustained-release tablets 10 mg twice daily.One year later,he developed gingival hyperplasia with bleeding and pain.After the treatment with roxithromycin,metronidazole and fenbufen capsules,his conditions did not improve.Drug-induced gingival hyperplasia was suspected,the nifedipine sustained-release tablets was discontinued and replaced with benazepril and metoprolol.One month later,his gingival hyperplasia disappeared.Afterwards,the patient took nifedipine sustained-release tablets 5 mg twice daily again because of poor control of his hypertension.Two months later,his gingival hyperplasia recurred.One month after stopping the drug,the symptom resolved again.