| 细胞DNA含量与大肠癌临床分期及生物学特性的关系 |
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| 引用本文： | 邹立群 赵霞. 细胞DNA含量与大肠癌临床分期及生物学特性的关系[J]. 华西医科大学学报, 2000, 31(2): 180-182 |
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| 作者姓名： | 邹立群 赵霞 |
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| 作者单位： | [1]华西医科大学附属第一医院肿瘤防治中心肿瘤生物治疗科 [2]附属第二医院妇产科 |
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| 摘 要： | 为进一步探讨大肠癌ＤＮＡ倍体与临床分期及生物学特性的关系，采用流式细胞仪对８６例大肠癌患者手术切除的新鲜大肠癌标本细胞ＤＮＡ含量进行了检测。结果显示：本组病例中４１例（４７．７％）为二倍体；４５例（５３．３％）为非二倍体。ＤＮＡ倍体与性别、年龄、分化程度、肿瘤部位无关，但与Ｄｕｋｅｓ’分期相关,Dukes’A期肿瘤病例DNA二倍体比Dukes’B、Ｃ、Ｄ期肿瘤病例更常见；Ｄｕｋｅｓ’Ｂ～Ｄ期肿瘤病例之间ＤＮＡ倍体
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| 关 键 词： | 大肠癌 DNA倍体 临床分期 生物学特性 |
The relationship of cellular DNA content with clinical stage and biological features of colorectal cancer] |
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| L Zou,Y Mao,S Lei,Y Wei,X Zhao,B Kan,Y Jiang,F Peng,Q Wang,L Tian,L Yang,J Liu. The relationship of cellular DNA content with clinical stage and biological features of colorectal cancer][J]. Journal of West China University of Medical Sciences, 2000, 31(2): 180-182 |
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| Authors: | L Zou Y Mao S Lei Y Wei X Zhao B Kan Y Jiang F Peng Q Wang L Tian L Yang J Liu |
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| Affiliation: | Department of Biotherapy for Cancer, First Affiliated Hospital, WCUMS, Chengdu 610041. |
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| Abstract: | The purpose of this study was to explore the relationship of cellular DNA content with clinical stage and biological features of cancer. Flow cytometry was performed on fresh specimens from 86 patients from 1997 to 1998. Forty-five (53.3%) specimens were found to contain cells with abnormal DNA (DNA nondiploidy). Although none of the sex, age, site, differentiation variables correlated with flow cytometric DNA ploidy, nondiploidy was associated with Dukes' stage and lymph node metastasis. Duke's A stage tumors were more frequently diploid than were more advanced tumors, but no difference between Duke's B, C and D stages were observed. These findings suggest that ploidy is associated with some pathological factors. |
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