Genetic basis of ventricular arrhythmias |
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Authors: | Boussy Tim Paparella Gaetano de Asmundis Carlo Sarkozy Andrea Chierchia Gian Battista Brugada Josep Brugada Ramon Brugada Pedro |
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Affiliation: | Heart Rhythm Management Institute, University Hospital Brussels, Belgium, Laarbeeklaan 101 - 1090 Brussels, Belgium. tboussy@yahoo.com |
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Abstract: | Sudden cardiac death caused by malignant ventricular arrhythmias is the most important cause of death in the industrialized world. Most of these lethal arrhythmias occur in the setting of ischemic heart disease. A significant number of sudden deaths, especially in young individuals, are caused by inherited ventricular arrhythmic disorders, however. Genetically induced ventricular arrhythmias can be divided in two subgroups: the primary electrical disorders or channelopathies, and the secondary arrhythmogenic cardiomyopathies. This article focuses on the genetic background of these electrical disorders and the current knowledge of genotype-phenotype interactions. |
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