某地区健康体检人群血清 AFP、CEA 血清水平的调查

目的：调查本地区健康体检人群血清 AFP、CEA 水平以及性别差异。方法（1）将健康体检人群按性别分为 A 组（男510例）和 B 组（女477例），（2）分别将 A 组和 B 组按年龄段分成：A1组（＜40岁）、A2组（40～＜50岁）、A3组（50～＜60岁）、A4组（60～＜70岁）、A5组（70～87岁）和 B1组（＜40岁）、B2组（40～＜50岁）、B3组（50～＜60岁）、B4组（60～＜70岁）、B5组（70～87岁），采用电化学发光免疫分析技术对987例健康体检人员的血清 AFP、CEA 进行检测，将 A 组和 B 组比较看有无统计学差异；A 组各组间比较看有无统计学差异，B 组各组间比较看有无统计学差异。结果（1）A 组和 B 组比较，AFP 和 CEA结果差异有统计学意义（P ＜0．01）；（2）A 组各亚组间比较 AFP 和 CEA 均无差异；B 组各亚组间比较 AFP 和 CEA 均无差异。结论本地区健康体检人群男女之间 AFP 和 CEA 血清含量有差异，且男性 AFP 和 CEA 血清含量明显高于女性，提示应该按性别分别建立 AFP 和 CEA 的参考范围；而 AFP 和 CEA 的血清含量在男女各年龄组间均无差异。

Investigation on serum AFP and CEA levels in healthy physical examination people in save area

Objective To investigate the levels of serum AFP and CEA in healthy physical examination people and their sexual difference.Methods （1 ）Healthy physical examination people were divided into the group A（510 males）and group B（477 fe-males）;（2）these two groups were subdivided into the group A1 （〈40 years old）,A2 （40 - 〈50 years old）,A3 （50 - 〈60 years old）,A4（60-〈70 years old）and A5 （70 -87 years old）,and group B1 （〈40 years old）,B2（40 -〈50 years old）,B3 （50 -〈60 years old）,B4（60-〈70 years old）and B5（70-87 years old）.The serum AFP and CEA in 987 healthy physical examination peo-ple were measured by the electrochemiluminesence immunoassay,and then the detection results were compared among various groups.Results （1）The detection results of serum AFP and CEA had statistically significant differences between the group A and B （P 〈0.01）;（2）there was no statistical differences among the group A and among the group B.Conclusion The serum AFP and CEA levels in healthy physical examination people in the local area have difference between males and females,which in males are significantly higher than those in females,indicating that the reference range of AFP and CEA should be repectively established ac-cording to different sexes;while the serum AFP and CEA levels have no differences among various age groups in males and fe-males.