低分子肝素钙联合灯盏花素治疗对老年肺源性心脏病急性发作期 NO、ET-1水平的影响

目的：探讨低分子肝素钙联合灯盏花素对老年慢性肺源性心脏病（简称肺心病）急性发作期的治疗效果及发病机制。方法将2011年10月至2013年6月在本院住院的共86例确诊的老年肺心病患者随机分为两组，两组患者年龄、性别、病情无显著差异，其中治疗组44例，对照组42例。两组均给予常规治疗，治疗组在常规治疗基础上加用低分子肝素钙和灯盏花素。观察两组患者治疗后临床症状改善及 NO、ET-1水平的改变情况。结果两组患者临床疗效总有效率分别为90．1％和71．4％；两组患者 NO、ET-1水平均有明显改善，治疗组疗效优于对照组，差异有统计学意义（P ＜0．05）。结论低分子肝素钙和灯盏花素联用能显著改善老年肺心病患者的症状，降低肺动脉压，减轻右心室负荷，可引起 NO、ET-1水平的改善，不良反应小。

Effects of low molecular weight heparin calcium combined with breviscapini on plasma NO and ET-1 in acute exacerbation of elderly chronic pulmonary heart disease

Objective To investigate the effect of low molecular weight heparin calcium combined with breviscapini in treating a-cute exacerbation of elderly chronic pulmonary heart disease and its mechanism.Methods 86 patients with acute exacerbation of elderly chronic pulmonary heart disease in our hospital from October 2011 to June 2013 were randomly divided into two groups. There were no significant differences in age,gender and disease condition between the two groups.44 cases were in the therapy group and the other 42 cases were in the control group.Both two groups received the routine therepy.On this basis the therapy group was added with low molecular weight heparin calcium and breviscapini.Then the improvement of clinical symptoms and the changes of plasma nitric oxide （NO）and endothelin-l （ET-1）after treatment were observed in the two groups.Results The total effective rates in the therapy group and the control group were 90.1%and 71.4% respectively;the levels of plasma NO and ET-1 after treatment in the two groups were significantly improved,but the improvement in the therapy group was better than that in the control group with the statistical difference between them（P 〈0.05）.Conclusion Low molecular weight heparin calcium combined with breviscapini can significantly improve the symptoms in the ederly pulmonary heart disease,decrease the lung arterial press,re-lieve the load of right ventricle and affect the levels of plasma NO and ET-1 with less adverse reactions.