| IMA、hs-CRP、MYO、CK-MB、hs-cTnT 联合检测在急性冠脉综合症诊断中的价值比较 |
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| 引用本文： | 郭清芳,李星新,赖晓霏. IMA、hs-CRP、MYO、CK-MB、hs-cTnT 联合检测在急性冠脉综合症诊断中的价值比较[J]. 国际检验医学杂志, 2014, 0(14): 1861-1863 |
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| 作者姓名： | 郭清芳 李星新 赖晓霏 |
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| 作者单位： | 郭清芳 (重庆市西郊医院检验科 400050)； 李星新 (重庆市武警医院 400061)； 赖晓霏 (重庆医科大学附属第一医院,重庆,400016)； |
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| 摘 要： | 目的：探讨血清中缺血个儿蛋白（IMA）、超敏 C 反应蛋白（hs-CRP）、肌红蛋白（MYO）、肌酸激酶同工酶（CK-MB）、超敏肌钙蛋白（hs-cTnT）在急性冠状动脉综合征（ACS）患者早期诊断的价值。方法测定99例健康对照组和94例 ACS 患者（其中不稳定性心绞痛40例，非 ST 段抬高的心肌梗死即非 Q 波心肌梗死20例，ST 段抬高的心肌梗死即 Q 波心肌梗死34例）中IMA、hs-CRP、MYO、CK-MB、hs-TNT 的含量。通过 ROC 曲线比较5种标志物在 ACS 早期诊断中的诊断效率、灵敏度、特异性、阴阳性预测值。结果血清中 IAM、hs-CRP、MYO、CK-MB、hs-cTnT 检测结果在病例组 UAP，NSTEMI，STEMI 3组和正常对照组间比较，差异均有统计学意义（P ＜0．05）。其中 IMA、hs-CRP、MYO、CK-MB、hs-cTnT 在 UAP 与 NSTEMI 组，UAP 与NSTEMI 组间比较，差异均有统计学意义（P ＜0．05），NSTEMI 与 STEMI 组间比较，差异均无统计学意义（P ＞0．05）。结论在ACS 中，多个指标的联合检测能取得早期诊断的价值。
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| 关 键 词： | 缺血修饰蛋白 超敏C反应蛋白 肌红蛋白 肌酸激酶同工酶 超敏肌钙蛋白T |
Comparison of diagnosis values of combined detection of IAM,hs-CRP,MYO,CK-MB,hs-cTnT in acute coronary syndrome |
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| Affiliation: | Guo Qingfang, Li Xingxin, Lai Xiaofei (1. Department of Clinical Laboratory ,Chongqing Municipal Xijiao Hospital ,Chongqing 400050 ,China 2. Chongqing Armed Police Hospital, Chongqing 400061, China ; 3. First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China) |
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| Abstract: | Objective To investigate the value of serum ischemia-modified protein （IMA）,hypersensitivity C reaction protein （hs-CRP）,myoglobin （MYO）creatine kinase MB （CK-MB）and ultra-sensitivity troponin T （hs-cTnT）in the early diagnosis of patients with acute coronary syndrome（ACS）.Methods Serum levels of IMA,hs-CRP,MYO,CK-MB and hs-cTnT were meaused in 94 patients with ACS[including 40 cases of unstable angina pectoris（UAP）,20 cases of non-ST segment elevation myocardial in-farction（NSTEMI）,non-Q wave myocardial infarction and 34 cases of ST segment elevation myocardial infarction（STEMI）,Q wave myocardial infarction]and 99 cases of controls.The efficiency,sensitivity,specificity,negative and positive predictive values in the early diagnosis of ACS were compared among 5 kinds markers by the ROC curve.Results The detection results of serum IMA,hs-CRP,MYO,CK-MB and hs-cTnT had statistically significant differences between the UAP,NSTEMI and STEMI groups with the normal control group （P 〈0.05）,serum IMA,hs-CRP,MYO,CK-MB and hs-cTnT had statistically significant differences between the UAP group with the NSTEMI group and between the UAP group with STEMI group （P 〈0.05）,but the difference between NSTEMI and STEMI group group was not statistically significant （P 〉0.05）.Conclusion In the patients with ACS,the multiple indicators combined detection can achieve the early diagnostic value. |
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| Keywords: | ischemia modified protein hypersensitive C reactive protein myoglobin creatine kinase MB ultra-sensitive troponin T acute coronary syndrome |
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